Objective: To study a suppository for treating cervical erosion, its preparation method, and to observe its therapeutic effect on cervical erosion in animal models. Methods: Twenty rats were divided into five groups: blank control group, model group, and three different therapeutic concentration groups. Phenol slurry was injected through the vagina to create cervical erosion animal models. After seven days of drug treatment, the difference of cervical histopathology was observed and compared between different groups. Results: Compared with the control group, the model group showed obvious cervical erosion, inflammatory cell infiltration, vascular dilatation, and congestion. Among the administration group, the high administration group had the least inflammation and cell infiltration in the mucous membrane. Conclusions: There is a significant effect of therapeutic drugs in rats with cervical erosion, which is related to the concentration of drugs.