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Original Research
Effects of early-cleavage embryo transfer on in vitro fertilization-embryo transfer pregnancy outcomes
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1
Reproductive Medical Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou (China)
Clin. Exp. Obstet. Gynecol. 2013, 40(3), 319–322;
Published: 10 September 2013
Abstract
Purpose: To observe the effects of early-cleavage embryo transfer (ET) on pregnancy outcomes in vitro fertilization-embryo transfer (IVFET). Materials and Methods: The data of 6,548 two pro-nucleate (2PN) embryos and 968 patients who underwent IVF or intracytoplasmic sperm injection (ICSI) were analyzed. Of the 968 cycles, early-cleavage embryos were used in 432 cycles (early-cleavage group), late-cleavage embryos were used in 246 cycles (late-cleavage group), and both early and late-cleavage embryos were used in 290 cycles (mixed group). Results: High-quality embryo rate was significantly higher in early-cleavage group than in late-cleavage group (82.74% vs 59.83%; p < 0.01). Both clinical pregnancy and implantation rates in IVF or ICSI were significantly higher in early-cleavage group than in late-cleavage group (all p < 0.01). In ICSI, both clinical pregnancy and implantation rates were significantly higher in mixed group than in late-cleavage group (all p < 0.05). Conclusion: Early-cleavage ET can improve pregnancy outcomes in IVF or ICSI.
Keywords
Clinical pregnancy rate
Early cleavage
High-quality embryo
Implantation rate