Purpose: By presenting anecdotal cases of women who conceived with IVF-ET despite very poor odds, this editorial hopes to make some of the infertility specialists to be more optimistic about the prognosis for pregnancy in women with diminished oocyte reserve. Methods: Description of Case Report where despite poor odds the couples elected to still attempt IVF-ET which appeared to be needed for conception to be possible. Results: Five cases are presented where the couple was willing to deplete their financial resources to achieve a pregnancy with IVF-ET using their own gametes and were eventually successful. Conclusions: Physicians should restrain from being dogmatic and present all options to patients not merely the physicians’ preference. It is embarrassing for a physician to insist that successful pregnancy is impossible only for the patient to prove that physician wrong. After receiving proper data patients should be allowed greater input into their treatment decision.