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Original Research
Morphologic and functional vascular alte rations in patients with polycystic ovary syndrome
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1
Department of Gyneacology and Obstetrics, Ergani State Hospital, Diyarbakir
2
Department of lnternal Diseases, Adiyaman University, Medicine Faculty, Adiyaman
3
Department of Radiodiagnostics，Ergani State Hospital，Diyarbakir
4
Department of Internal Medicine, Diyarbakir Family Hospital, Diyarbakir
5
Department of Biochemistry, Dicle University, Medicine Faculty, Diyarbakir
6
Department of Gyneacology and Obstetrics, Dicle University, Medicine Faculty, Diyarbakir (Turkey)
Clin. Exp. Obstet. Gynecol. 2011, 38(4), 401–404;
Published: 10 December 2011
Abstract
Background: We aimed to investigate morphologic and functional alterations of common carotid arteries(CCA) and femoral arteries and the anteroposterior diameter of the abdominal aorta in patients with polycystic ovary syndrome(PCOS). Materials and Methods: Fifty consecutive females with the complaint of oligoamenorrhea, infertility or hirsutismus, diagnosed with COS and 50 healthy females admitted to the Department of Gynecology and Obstetrics, Ergani State Hospital between January 2010 and January20ll were included in the study. Results: The mean BMi of 50 patients with PCOS was higher than control subjects (CS) (25.89 ± 3.3 vs. 22.52 ± 2.7 kg/m2, p < 0.0001). The mean arterial blood pressure was 88.93 ± 6.4 mmHg in the patient group and was it 85.73 ± 7.6 mmHg in CS (p = 0.02).The mean plasma glucose level (74.04 ± 6.7 vs. 70.5 ± 6.4 mg/dl, total cholesterol level (167.88 ± 30.1 vs. 153.38 ± 27.8 mg/dl), low density lipoprotein level (101.28 ± 27.0 vs. 79.56 ± 25.5 mg/dl) and triglyceride level (121.22 ± 49.2 vs. 102.54 ± 36.6 mg/dl) were higher; also the mean high density lipoprotein level (44.56 ± 8.1 vs. 50.90 ± 12.3 mg/(dl) was lower in patients with PCOS than CS (p = 0.009, p =0.014, p < 0.0001, p =0.034 and p = 0.003, respectively). CCA-IMT (0.63 ± 0.2 vs. 0.52 ± 0.1 mm), and CCA-PI (1.4 ± 0.3 vs 1.28 ± 0.22) were higher in patients with PCOS (p = 0.018 and p = 0.005, respetively). Femora-IMT (0.62 ± 0.6 vs. 0.41 ± 0.1 mm) and anteroposterior diameter of the infrarenal aorta (12.34 ± 1.5 vs. 11.4 ± 1.0 mm) were higher in patients with PCOS (p = 0.024 and p = 0.001, respectively). Conclusion: The present study showed that IMT and Pl of CCA, and anteroposterior diameter of the infrarenal abdominal aorta and femoral-IMT were higher in patients with PCOS. These results are probably related with increased androgens, their effects on insulin resistance and lipid profile, increased BMI and blood pressure. Detection of these functional andor structural abnormalities are important in predicting prognosis. Larger scale prospective studies are needed to determine the effects of PCOS on the mortality and morbidity, and to clarify the relation between the duration of the disease and development of these alterations.
Keywords
Polycystic ovary syndrome
Vascular alterations
Vascular dysfunction