IMR Press / CEOG / Volume 38 / Issue 2 / pii/1630488776174-1176154937

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Open Access Original Research
Efficacy of vaginal use of topical estriol in postmenopausal women with urogenital atrophy
Show Less
1 Gynecology Department, Universidade Federal de Sao Paulo (EPM-UNIFESP), Sao Paulo, SP (Brazil)
Clin. Exp. Obstet. Gynecol. 2011, 38(2), 143–145;
Published: 10 June 2011
Abstract

Objective: This study evaluates the effect of intravaginal estriol on urogenital atrophy, Pap smear parameters, colposcopy parameters and discomfort during gynecological examination. Methods: 31 postmenopausal women who had not used hormone therapy in the previous six months were studied. All women used intravaginal estriol, 1 mg/day for 21 days. The following variables were analyzed before and after treatment: complaints of urogenital atrophy; cytological parameters, colposcopic parameters, and subjective evaluation of discomfort during gynecologic examination. Results: All urogenital atrophy complaints improved after treatment. At the first visit, 45.2% of women presented a predominance of profound cells, 5 1.6% with predominance of intermediate cells, and 3.2% with predominance of superficial cells. At the second visit, these rates were 35.5%, 64.5%, and 0%, respectively. Evaluation of the maturation index showed that 83.9% of women had atrophic Pap smears, and 16. l % showed good estrogenic level before treatment. At the second visit, atrophic smears occurred in 12.9%, and 87.1 % of women exhibited good estrogenic level (x2 = 20.045; p = 0.000). Colposcopy showed that 71% of women had atrophic colpitis and/or petequiae before treatment, while atrophy after therapy was present in only 6.4%. The evaluation of other colposcopic parameters also improved after treatment. Great discomfort was reported by 19.4% before and by 0% after treatment. Conclusion: Intravaginal estriol 1 mg/day for a period of 21 days was efficient in improving urogenital atrophy, Pap smear parameters and colposcopic evaluation in postmenopausal women.
Keywords
Vaginal smears
Colposcopy
Post menopause
Estriol
Topical estrogen therapy
Share
Back to top