Purpose: To demonstrate the benefits of using lower dosage FSH stimulation for follicular maturation in in vitro fertilization (IVF) cycles and in non-IVF cycles. Methods: Several studies are evaluated in which either high or lower dosage gonadotropins were used in IVF and non-IVF cycles. The patient population were women either with diminished or normal ovarian egg reserve. Results: Very poor pregnancy rates were found with high dosage gonadotropins when there was diminished egg reserve. In contrast pregnancy results per transfer were comparable to women with normal egg reserve when low dose gonadotropin regimens were used. Conclusions: Low dose gonadotropin regimens have the benefit of reducing costs and risks of ovarian hyperstimulation without reducing efficacy and in some cases actually increasing pregnancy rates.