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Cite this article
Chorionic villus sampling: analysis of the first 350 singleton pregnancies by a single operator
1 Prenatal Diagnosis & Therapy Centre, College of Medicine, University of Lagos, Surulere, Lagos (Nigeria)
Clin. Exp. Obstet. Gynecol. 2009, 36(4), 251–253;
Published: 10 December 2009
Objective: To assess factors that might influence the success rate, safety and reliability of chorionic villus sampling (CVS). Design: Analysis of the outcome of 350 cases of CVS (215 transabdominal and 135 transvaginal). Setting: The outpatient prenatal diagnosis and therapy laboratory of a university tertiary care centre. Subjects: 350 pregnant women that underwent CVS for prenatal genetic diagnosis between nine and 32 gestational weeks. Results: Fetal genotype was the most common indication for CVS 45% (158/350). The overall sampling success rate was 98% (343/350). The majority of cases, 92% (322/350), required one or two aspirations. Out of 331 cases in which CVS was successful 305 continued with the pregnancy. Thirty-five had therapeutic termination of their pregnancies and ten resulted in spontaneous abortions. There was an overall fetal loss rate of 1.7% (6/350). Early bleeding complications occurred in 11.4% (40/350). PROM 0.86% (3/350), preterm 5.1% (18/350), and placenta disorders 1.1% (4/350) did not exceed the expected values. Conclusion: CVS is a relatively safe and reliable method of prenatal genetic diagnosis. It needs be done by experienced personnel.
Chorionic villous sampling
Prenatal genetic diagnosis