Objective: To investigate the efficacy of vaginal administration of 800 μg misoprostol as a single dose without performing post expulsion systematic curettage in first trimester pregnancy termination. Method: 113 women, aged 16-44, who requested first trimester pregnancy termination, received 800 μg of vaginal misoprostol. All examined women were divided into two groups depending on gestation age. The first group included of 67 women with up to nine weeks and the second of 46 with up to 12 weeks of pregnancy. Results: Abortion occurred within 24 hours and was completed in 74.3% of the cases. The mean induction-abortion interval was 5.9 ± 1.7 hours (median 5.5 hours). Side-effects were experienced by 24 women (21.2%). There was no significant difference between groups in the success rate, induction-abortion interval, number of previous deliveries and side-effects. Conclusion: Misoprostol is an effective agent for first trimester medical termination.