Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Successful pregnancy with spontaneous ovulation in a woman with apparent premature ovarian failure who failed to conceive despite four transfers of embryos derived from donated oocytes
Purpose: To show that successful pregnancy is possible in a woman in apparent premature ovarian failure despite a serum follicle stimulating hormone (FSH) > 100 pg/mL. Methods: The high serum FSH was lowered with ethinyl estradiol. Progesterone (P) supplementation was to be used if ovulation was achieved. Results: Successful ovulation x2 was achieved by using 0.02 mg ethinyl estradiol. Progesterone vaginal suppositories (200 mg) twice daily were used in the luteal phase. Unfortunately pregnancy was not achieved. The couple elected to try donor oocytes after failing to ovulate on the third cycle. The patient spontaneously ovulated and conceived immediately after failing to become pregnant with four donor-oocyte transfers. Conclusions: The suspicion was that the graduated dosage of estrogen used for the donor-oocyte cycles suppressed the FSH allowing her to respond to endogenous gonadotropins.