IMR Press / CEOG / Volume 28 / Issue 4 / pii/2001066

Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

The conventional doses of human chorionic gonadotropins may not always be sufficient to induce ovulation in all women: A reappraisal

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1 Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut (USA)
2 Division of Medical Genetics, Brigham and Women’s Hospital, Boston, MA (USA)
3 Division of Medical Endocrinology, Rizk Hospital, Beirut (Lebanon)
Clin. Exp. Obstet. Gynecol. 2001, 28(4), 240–242;
Published: 10 December 2001

Background: Failure of ovulation has occasionally been reported following the administration of conventionally recommended doses of exogenous human chorionic gonadotropins. Case: A 25-year-old nulliparous woman with polycystic ovary syndrome underwent ovulation induction for primary infertility. Fol­lowing successful ovarian stimulation, she failed to ovulate during two consecutive cycles in response to human chorionic gonadotro­pin doses of 5,000 and 10,000 IU. When challenged with a higher than conventional dose (15,000 IU) on the third cycle, she ovulated and conceived. Conclusion: Conventional doses of exogenous human chorionic gonadotropins occasionally fail to complete the ovulatory process in some women. Women with polycystic ovary syndrome appear to be particularly susceptible. Routine documentation of ovulation and individualization of the dose of exogenous human chorionic gonadotropins could therefore prove to be useful in some of these women in order to achieve the best treatment outcome.

Ovulation induction
Polycystic ovary syndrome
Human chorionic gonadotropins
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