Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Comparison of the resorbable barrier Interceed (TC7) and preoperative use of medroxyprogesterone acetate in postoperative adhesion prevention
Purpose: The purpose of this study was to compare the effectiveness of barrier agent Interceed (TC7) (Johnson & Johnson Medical, Inc) and preoperative use of commonly used progesterone, medroxyprogesterone acetate. Methods: Forty-five Spraque-Dawley white rats of reproductive age (225-250 g) were employed as a model for postsurgical adhesion formation. Group 1 consisted of control rats, Group 2 consisted only of rats with Interceed applied to the denuded areas, Group 3 consisted of rats where preoperative MPA was used. Fifteen rats were exposed to daily IM injections of 15 mg medroxyprogesterone acetate (MPA) two weeks before the surgery. Results: The total adhesion score of the MPA group was significantly less than the control and Interceed group respectively (x2 = 10.15) (p < 0.001), (x2 = 4.67) (p < 0.03). There was no significant difference between the Interceed and the control group (p > 0.05). Conclusion: Preoperative long-term MPA treatment significantly decreases primary adhesion formation. It seems that there are some other mechanisms responsible for this effect rather than anti-inflammation and/or immunosuppression. It may be that the hypoestrogenic milieu depends on the use of progesterone.