Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Prostaglandin F1a and prostaglandin E2 plasma levels after transvaginal cervical cerclage
Plasma prostaglandin metabolites, prostaglandin F1a (PGF1a) and prostaglandin E2 (PGE2) were measured in a serial set of maternal serum samples by radiolmmunoassay after elective transvaginal cervical cerclage (Shirodkar) in 18 patients early in the 2nd trimester (14-15 weeks of gestation) for a history of cervical incompetence. Eight patients received progesterone preoperatively as a myometrial suppressant. The basal PGF1a. and PGE2 were 134.0 ± 25.9 pg/mL and 14.9 ± 1.8 pg/mL, respectively. A gradual rise in both metabolites was observed within 1 hour after the operation (206.81 ± 48.3 pg/mL and 16.7 ± 1.6 pg/mL, respectively, p > 0.05), peaking at 6 hours (265.4 ± 51.8 pg/mL, p < 0.01 and 25.9 ± 4.9 pg/mL, p <.05), and falling to basal levels within 24 hours (136.7 ± 26.5 pg/mL and 14.0 ± 1.2 pg/mL, respectively, p > 0.05). The increase in PGF1a, was proportionately greater than PGE, metabolite (r = 0.838, p < 0.001). No differences were found in prostaglandin levels amongst patients who received progesterone as compared to the non-recipients for all the time intervals studied (p < 0.05). Our findings, further suggest that a temporary increase in prostaglandin production occurs following cervical cerclage, but its role remains unclear.