Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 46 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
The main viruses responsible for condyloma, a venereal disease, are the HPV 16 and 11. The stages of HPV infection are under the control of the immunitary system, which is inhibited by the virus itself. For this reason, the therapy of cervical condylomatosis is, at present, based on the use of interferon. The purpose of this study was to appreciate the activation of the immune system after therapy with interferon. We treated 12 women suffering from cervical condyloma and exocervicaI CIN with increasing doses of natural alpha-IFN injected intramuscularly, and also applied to the vagina. The clinical response to the therapy was total in 7 cases, partial in 4 cases and unsuccessful in 1 case. We also evaluated the percentage of inflammatory cells in the peripheral blood and at the level of the condylomatous lesions. After treatment the absolute and percentage number of inflammatory cells increased. Besides, at the level of the lesion the CDl and CD4 cells also increased.