The Predictive Value of PAPP-A for Threatened Miscarriage in Pregnant Women at 11–14 Weeks of Gestation: A Case-Control Study—Graphic Abstract

Pregnancy-associated plasma protein A (PAPP-A) is a glycoprotein produced by placental trophoblasts and serves as an important biomarker in early pregnancy diagnosis. Low PAPP-A levels in the first trimester have been associated with increased risks of adverse outcomes, including threatened miscarriage. This study aimed to evaluate PAPP-A levels in women with threatened miscarriage and assess its value in early diagnosis. A comparison was made between women with threatened miscarriage and healthy pregnant women at 11–14 weeks of gestation. The results showed that PAPP-A levels were significantly lower in the threatened miscarriage group. Additionally, the threatened miscarriage group showed a higher proportion of underweight individuals, as well as greater gestational age, crown-rump length, and nuchal translucency (NT) values. Among these factors, PAPP-A levels and NT were identified as independent negative and positive predictors, respectively, of threatened miscarriage. Receiver operating characteristic (ROC) curve analysis indicated that PAPP-A had promising diagnostic potential, showing high sensitivity and relatively high specificity in distinguishing between the two groups. These findings suggest that PAPP-A is a moderately useful marker for early prediction and management of threatened miscarriage.

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The Predictive Value of PAPP-A for Threatened Miscarriage in Pregnant Women at 11–14 Weeks of Gestation: A Case-Control Study: https://www.imrpress.com/journal/CEOG/52/5/10.31083/CEOG28246

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