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International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Volume 21, Issue 3 (May 2025)
Virtual Screening of Representative Natural Products Library for TGF-β-Mediated Liver Cirrhosis: An in silico and in vitro Multi-Target Study
Virtual Screening of Representative Natural Products Library for TGF-β-Mediated Liver Cirrhosis: An in silico and in vitro Multi-Target Study
Int. J. Pharmacol. 2025, 21(3), 521–540; https://doi.org/10.3923/ijp.2025.521.540
Effects of Ferulic Acid Regulation of the PI3k/Akt Signaling Pathway on the Proliferation, Migration or Apoptosis of U87-MG Cells Based on Bioinformatics
Effects of Ferulic Acid Regulation of the PI3k/Akt Signaling Pathway on the Proliferation, Migration or Apoptosis of U87-MG Cells Based on Bioinformatics
Int. J. Pharmacol. 2025, 21(3), 510–520; https://doi.org/10.3923/ijp.2025.510.520
Lupeol Protects Neuronal Injury Against Spinal Cord Injury in Rat Models via Targeting Nf-κB/NLRP3 Activation
Lupeol Protects Neuronal Injury Against Spinal Cord Injury in Rat Models via Targeting Nf-κB/NLRP3 Activation
Int. J. Pharmacol. 2025, 21(3), 502–509; https://doi.org/10.3923/ijp.2025.502.509
Acidified Bile Acid-Induced ROS Facilitates Stemness and Proliferation of Gastric Cancer Cells
Acidified Bile Acid-Induced ROS Facilitates Stemness and Proliferation of Gastric Cancer Cells
Int. J. Pharmacol. 2025, 21(3), 489–501; https://doi.org/10.3923/ijp.2025.489.501
Exploring the Mechanism of Action of Ru-Pi-Xiao on Treating Mammary Gland Hyperplasia Based on Network Pharmacology and Molecular Docking Technology
Exploring the Mechanism of Action of Ru-Pi-Xiao on Treating Mammary Gland Hyperplasia Based on Network Pharmacology and Molecular Docking Technology
Int. J. Pharmacol. 2025, 21(3), 475–488; https://doi.org/10.3923/ijp.2025.475.488
N-Methylcoclaurine Suppresses Hepatocellular Carcinoma by Inhibiting Protein Disulfide Isomerase in vitro and in vivo
N-Methylcoclaurine Suppresses Hepatocellular Carcinoma by Inhibiting Protein Disulfide Isomerase in vitro and in vivo
Int. J. Pharmacol. 2025, 21(3), 464–474; https://doi.org/10.3923/ijp.2025.464.474
Effects of Loading TAB2 siRNA and Cisplatin Nano-Liposomes Mediated Macrophage Polarization on Drug Resistance, Proliferation and Metastasis of Ovarian Cancer Cells
Effects of Loading TAB2 siRNA and Cisplatin Nano-Liposomes Mediated Macrophage Polarization on Drug Resistance, Proliferation and Metastasis of Ovarian Cancer Cells
Int. J. Pharmacol. 2025, 21(3), 453–463; https://doi.org/10.3923/ijp.2025.453.463
Effect of Electricity on the Expression of CGRP and its Receptor RAMP1 in Rat IBS-C Model and its Mechanism of Action
Effect of Electricity on the Expression of CGRP and its Receptor RAMP1 in Rat IBS-C Model and its Mechanism of Action
Int. J. Pharmacol. 2025, 21(3), 443–452; https://doi.org/10.3923/ijp.2025.443.452
Design, Synthesis Optimization and Anticancer Activity of Small Molecule Kinase Inhibitors
Design, Synthesis Optimization and Anticancer Activity of Small Molecule Kinase Inhibitors
Int. J. Pharmacol. 2025, 21(3), 429–442; https://doi.org/10.3923/ijp.2025.429.442
Carvacrol Inhibits the Proliferation and Extracellular Matrix Deposition of Keloid Fibroblasts Through Nrf2/GPX4 and TGF-β1/Smad Signaling Pathways
Carvacrol Inhibits the Proliferation and Extracellular Matrix Deposition of Keloid Fibroblasts Through Nrf2/GPX4 and TGF-β1/Smad Signaling Pathways
Int. J. Pharmacol. 2025, 21(3), 419–428; https://doi.org/10.3923/ijp.2025.419.428
Efficacy and Safety of Topiroxostat in Patients with Chronic Kidney Disease and Hyperuricemia: A Meta-Analysis
Efficacy and Safety of Topiroxostat in Patients with Chronic Kidney Disease and Hyperuricemia: A Meta-Analysis
Int. J. Pharmacol. 2025, 21(3), 408–418; https://doi.org/10.3923/ijp.2025.408.418
Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension
Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension
Int. J. Pharmacol. 2025, 21(3), 401–407; https://doi.org/10.3923/ijp.2025.401.407
Mechanism of Quercetin Mediating PI3K/Akt/mTOR Pathway in Alleviating Cerebral Vascular Stenosis Caused by Vascular Endothelial Cell Injury
Mechanism of Quercetin Mediating PI3K/Akt/mTOR Pathway in Alleviating Cerebral Vascular Stenosis Caused by Vascular Endothelial Cell Injury
Int. J. Pharmacol. 2025, 21(3), 391–400; https://doi.org/10.3923/ijp.2025.391.400
Molecular and Functional Analysis of TXNDC11 in Neuro2a Neuroblastoma Cells: A Potential Drug Target in ER Stress-Associated Disorders
Molecular and Functional Analysis of TXNDC11 in Neuro2a Neuroblastoma Cells: A Potential Drug Target in ER Stress-Associated Disorders
Int. J. Pharmacol. 2025, 21(3), 378–390; https://doi.org/10.3923/ijp.2025.378.390
Combination Therapy of Trastuzumab and Lapatinib in Chemorefractory HER2-Positive Metastatic Colorectal Cancer: An Efficacy and Safety Analysis
Combination Therapy of Trastuzumab and Lapatinib in Chemorefractory HER2-Positive Metastatic Colorectal Cancer: An Efficacy and Safety Analysis
Int. J. Pharmacol. 2025, 21(3), 369–377; https://doi.org/10.3923/ijp.2025.369.377
Antitumoral Effect of Tomentosin from Inula viscosa Plant on Mice with Ehrlich Acid Tumor
Antitumoral Effect of Tomentosin from Inula viscosa Plant on Mice with Ehrlich Acid Tumor
Int. J. Pharmacol. 2025, 21(3), 357–368; https://doi.org/10.3923/ijp.2025.357.368
Cyclosporine Transporter Pharmacogenomic Effect in Transplantation: An Updated Systematic Review
Cyclosporine Transporter Pharmacogenomic Effect in Transplantation: An Updated Systematic Review
Int. J. Pharmacol. 2025, 21(3), 345–356; https://doi.org/10.3923/ijp.2025.345.356
Effects of Levosimendan on Hemodynamics and Prognosis in Patients with Sepsis: A Meta-Analysis and Systematic Review
Effects of Levosimendan on Hemodynamics and Prognosis in Patients with Sepsis: A Meta-Analysis and Systematic Review
Int. J. Pharmacol. 2025, 21(3), 334–344; https://doi.org/10.3923/ijp.2025.334.344
Impact of Tacrolimus Versus Cyclosporine on Overall Response, Complete Remission and Relapse in Nephrotic Syndrome: A Systematic Review and Meta-Analysis
Impact of Tacrolimus Versus Cyclosporine on Overall Response, Complete Remission and Relapse in Nephrotic Syndrome: A Systematic Review and Meta-Analysis
Int. J. Pharmacol. 2025, 21(3), 324–333; https://doi.org/10.3923/ijp.2025.324.333
International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
Volume 21, Issue 3 (2025)
Journal Browser
Forthcoming Issue
Current Issue
Article
Virtual Screening of Representative Natural Products Library for TGF-β-Mediated Liver Cirrhosis: An in silico and in vitro Multi-Target Study
Virtual Screening of Representative Natural Products Library for TGF-β-Mediated Liver Cirrhosis: An in silico and in vitro Multi-Target Study
Int. J. Pharmacol. 2025, 21(3), 521–540; https://doi.org/10.3923/ijp.2025.521.540
Effects of Ferulic Acid Regulation of the PI3k/Akt Signaling Pathway on the Proliferation, Migration or Apoptosis of U87-MG Cells Based on Bioinformatics
Effects of Ferulic Acid Regulation of the PI3k/Akt Signaling Pathway on the Proliferation, Migration or Apoptosis of U87-MG Cells Based on Bioinformatics
Int. J. Pharmacol. 2025, 21(3), 510–520; https://doi.org/10.3923/ijp.2025.510.520
Lupeol Protects Neuronal Injury Against Spinal Cord Injury in Rat Models via Targeting Nf-κB/NLRP3 Activation
Lupeol Protects Neuronal Injury Against Spinal Cord Injury in Rat Models via Targeting Nf-κB/NLRP3 Activation
Int. J. Pharmacol. 2025, 21(3), 502–509; https://doi.org/10.3923/ijp.2025.502.509
Acidified Bile Acid-Induced ROS Facilitates Stemness and Proliferation of Gastric Cancer Cells
Acidified Bile Acid-Induced ROS Facilitates Stemness and Proliferation of Gastric Cancer Cells
Int. J. Pharmacol. 2025, 21(3), 489–501; https://doi.org/10.3923/ijp.2025.489.501
Exploring the Mechanism of Action of Ru-Pi-Xiao on Treating Mammary Gland Hyperplasia Based on Network Pharmacology and Molecular Docking Technology
Exploring the Mechanism of Action of Ru-Pi-Xiao on Treating Mammary Gland Hyperplasia Based on Network Pharmacology and Molecular Docking Technology
Int. J. Pharmacol. 2025, 21(3), 475–488; https://doi.org/10.3923/ijp.2025.475.488
N-Methylcoclaurine Suppresses Hepatocellular Carcinoma by Inhibiting Protein Disulfide Isomerase in vitro and in vivo
N-Methylcoclaurine Suppresses Hepatocellular Carcinoma by Inhibiting Protein Disulfide Isomerase in vitro and in vivo
Int. J. Pharmacol. 2025, 21(3), 464–474; https://doi.org/10.3923/ijp.2025.464.474
Effects of Loading TAB2 siRNA and Cisplatin Nano-Liposomes Mediated Macrophage Polarization on Drug Resistance, Proliferation and Metastasis of Ovarian Cancer Cells
Effects of Loading TAB2 siRNA and Cisplatin Nano-Liposomes Mediated Macrophage Polarization on Drug Resistance, Proliferation and Metastasis of Ovarian Cancer Cells
Int. J. Pharmacol. 2025, 21(3), 453–463; https://doi.org/10.3923/ijp.2025.453.463
Effect of Electricity on the Expression of CGRP and its Receptor RAMP1 in Rat IBS-C Model and its Mechanism of Action
Effect of Electricity on the Expression of CGRP and its Receptor RAMP1 in Rat IBS-C Model and its Mechanism of Action
Int. J. Pharmacol. 2025, 21(3), 443–452; https://doi.org/10.3923/ijp.2025.443.452
Design, Synthesis Optimization and Anticancer Activity of Small Molecule Kinase Inhibitors
Design, Synthesis Optimization and Anticancer Activity of Small Molecule Kinase Inhibitors
Int. J. Pharmacol. 2025, 21(3), 429–442; https://doi.org/10.3923/ijp.2025.429.442
Carvacrol Inhibits the Proliferation and Extracellular Matrix Deposition of Keloid Fibroblasts Through Nrf2/GPX4 and TGF-β1/Smad Signaling Pathways
Carvacrol Inhibits the Proliferation and Extracellular Matrix Deposition of Keloid Fibroblasts Through Nrf2/GPX4 and TGF-β1/Smad Signaling Pathways
Int. J. Pharmacol. 2025, 21(3), 419–428; https://doi.org/10.3923/ijp.2025.419.428
Efficacy and Safety of Topiroxostat in Patients with Chronic Kidney Disease and Hyperuricemia: A Meta-Analysis
Efficacy and Safety of Topiroxostat in Patients with Chronic Kidney Disease and Hyperuricemia: A Meta-Analysis
Int. J. Pharmacol. 2025, 21(3), 408–418; https://doi.org/10.3923/ijp.2025.408.418
Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension
Effect of High Dose Folic Acid Supplementation on the Prevention of Pre-Eclampsia in Pregnancy with Hypertension
Int. J. Pharmacol. 2025, 21(3), 401–407; https://doi.org/10.3923/ijp.2025.401.407
Mechanism of Quercetin Mediating PI3K/Akt/mTOR Pathway in Alleviating Cerebral Vascular Stenosis Caused by Vascular Endothelial Cell Injury
Mechanism of Quercetin Mediating PI3K/Akt/mTOR Pathway in Alleviating Cerebral Vascular Stenosis Caused by Vascular Endothelial Cell Injury
Int. J. Pharmacol. 2025, 21(3), 391–400; https://doi.org/10.3923/ijp.2025.391.400
Molecular and Functional Analysis of TXNDC11 in Neuro2a Neuroblastoma Cells: A Potential Drug Target in ER Stress-Associated Disorders
Molecular and Functional Analysis of TXNDC11 in Neuro2a Neuroblastoma Cells: A Potential Drug Target in ER Stress-Associated Disorders
Int. J. Pharmacol. 2025, 21(3), 378–390; https://doi.org/10.3923/ijp.2025.378.390
Combination Therapy of Trastuzumab and Lapatinib in Chemorefractory HER2-Positive Metastatic Colorectal Cancer: An Efficacy and Safety Analysis
Combination Therapy of Trastuzumab and Lapatinib in Chemorefractory HER2-Positive Metastatic Colorectal Cancer: An Efficacy and Safety Analysis
Int. J. Pharmacol. 2025, 21(3), 369–377; https://doi.org/10.3923/ijp.2025.369.377
Antitumoral Effect of Tomentosin from Inula viscosa Plant on Mice with Ehrlich Acid Tumor
Antitumoral Effect of Tomentosin from Inula viscosa Plant on Mice with Ehrlich Acid Tumor
Int. J. Pharmacol. 2025, 21(3), 357–368; https://doi.org/10.3923/ijp.2025.357.368
Cyclosporine Transporter Pharmacogenomic Effect in Transplantation: An Updated Systematic Review
Cyclosporine Transporter Pharmacogenomic Effect in Transplantation: An Updated Systematic Review
Int. J. Pharmacol. 2025, 21(3), 345–356; https://doi.org/10.3923/ijp.2025.345.356
Effects of Levosimendan on Hemodynamics and Prognosis in Patients with Sepsis: A Meta-Analysis and Systematic Review
Effects of Levosimendan on Hemodynamics and Prognosis in Patients with Sepsis: A Meta-Analysis and Systematic Review
Int. J. Pharmacol. 2025, 21(3), 334–344; https://doi.org/10.3923/ijp.2025.334.344
Impact of Tacrolimus Versus Cyclosporine on Overall Response, Complete Remission and Relapse in Nephrotic Syndrome: A Systematic Review and Meta-Analysis
Impact of Tacrolimus Versus Cyclosporine on Overall Response, Complete Remission and Relapse in Nephrotic Syndrome: A Systematic Review and Meta-Analysis
Int. J. Pharmacol. 2025, 21(3), 324–333; https://doi.org/10.3923/ijp.2025.324.333