Parkinson’s disease (PD) is a common neurodegenerative disorder that can have a major impact on the quality of life and is characterized by both motor and non-motor clinical symptoms. The pathological hallmarks of PD are abnormal accumulation of alpha-synuclein aggregates, Lewy bodies, and Lewy neuritis. The alpha-synucleinopathy in PD involves dopaminergic neurons in the substantia nigra pars compacta of the midbrain, as well as other vulnerable neurotransmitter systems in the central nervous system. The pathophysiological mechanisms underlying various symptoms in patients with PD are still unclear. Both medication and surgical treatment can relieve the symptoms of PD patients, however fundamental treatments are still unavailable. This special edition will comprise papers that are pertinent to the study of PD. Major advances in PD research have been made in recent years and it is hoped this will be reflected in the manuscripts contained in this special edition. Potential topics include:

• Motor and non-motor features in Parkinson’s disease
• Neuroimaging in Parkinson’s disease
• Genetics and Epidemiology of Parkinson’s disease
• Medical treatment of Parkinson’s disease
• Surgical treatment of Parkinson’s disease

Dr. Ho-Sung Ryu

Guest editor