Dear Colleagues,

Neuropathic pain (NP) is defined as pain caused by a lesion or a disease of the somatosensory system. Neuropathic pain is becoming more prevalent due to an aging world population, the rising impact of diabetes mellitus as well as higher survival rates of cancer following the use of chemotherapy. Migraine is a neurological condition with a global prevalence. Despite the findings of clinical symptoms and signs consistent with neuropathic pain during migraine attacks, controversy remains as to whether episodic migraine or chronic migraine should be considered as neuropathic pain syndromes. In addition, several hypotheses suggest that repeated episodes of migraine headache are associated with changes in the structure or function of the central nervous system. Management of NP remains challenging, as many patients do not experience adequate pain relief. Recent human evidence for the treatment effects on neuropathic pain remains controversial.

The goal of this special issue is to help to understand the pain mechanisms of this pathology and to provide knowledge about the new treatment options. Preclinical and translational research manuscripts are requested. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to this topic.

Dr. Alfonso Gil-Martínez and Dr. Luis Matesanz-García

Guest Editors