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Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jun 2016Review

Interactions between bone cells and biomaterials: An update

Sabrina Beauvais 1, Olivier Drevelle 1,2, Jessica Jann 1, Marc-Antoine Lauzon 1, Mohammadreza Foruzanmehr 3, Guillaume Grenier 4,5, Sophie Roux 5,6, Nathalie Faucheux 1,5,*
Affiliations
Article Info

1 Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1

2 Ecole Polytechnique de Montreal, 2900, Blvd Edouard Montpetit, Montreal, Quebec, Canada, H3C 3A7

3 Universite de Sherbrooke, Carrefour d’Innovations en Technologies Ecologiques (CITE), 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1

4 Universite de Sherbrooke, Department of Surgery, 3001 12e Avenue N, Sherbrooke, Quebec, Canada, J1H 5N4

5 Centre de Recherche du CHUS, 3001 12e Avenue N, Sherbrooke, Quebec, J1H 5N4

6 Universite de Sherbrooke, Department of Medicine, 3001 12e Avenue N, Sherbrooke, Quebec, Canada, J1H 5N4

*Author to whom correspondence should be addressed.

 

Abstract

As the populations of the Western world become older, they will suffer more and more from bone defects related to osteoporosis (non-union fractures, vertebral damages), cancers (malignant osteolysis) and infections (osteomyelitis). Autografts are usually used to fill these defects, but they have several drawbacks such as morbidity at the donor site and the amount and quality of bone that can be harvested. Recent scientific milestones made in biomaterials development were shown to be promising to overcome these limitations. Cell interactions with biomaterials can be improved by adding at their surface functional groups such as adhesive peptides and/or growth factors. The development of such biomimetic materials able to control bone cell responses can only proceed if it is based on a sound understanding of bone cell behavior and regulation. This review focuses on bone physiology and the regulation of bone cell differentiation and function, and how the latest advances in biomimetic materials can be translated within promising clinical outcomes.

Keywords

  • Alpha Integrin Subunit
  • Adhesion
  • Angiogenesis
  • Apoptosis
  • Beta Integrin Subunit
  • Biomaterial
  • Biomimetic
  • BMP
  • Bone
  • Bone Remodeling
  • Bone Substitute
  • Collagen
  • Differentiation
  • ECM
  • Extracellular Matrix
  • Fibrillar Adhesion
  • Fibronectin
  • Focal Adhesion
  • Focal Complex
  • Growth Factor
  • GTPase
  • Healing
  • Integrin
  • Interaction
  • Kinase
  • MAPK
  • Osteoblast
  • Osteoclast
  • Osteoinduction
  • Osteoconduction
  • Osteocyte
  • Peptide
  • Polymer
  • Proliferation
  • Receptor
  • RGD
  • Scaffold
  • Signal Transduction
  • Smad
  • TGF
  • Vascularization
  • VEGF
  • Wnt
  • Review

References

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