IMR Press / FBS / Volume 7 / Issue 1 / DOI: 10.2741/S424

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Epigenetic crosstalk: a molecular language in human metabolic disorders
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1 Department of Biochemistry and Molecular Biology. University of Valencia. C/Doctor Moliner 50, 46100 - Burjassot, Valencia, Spain
2 Epigenetics and Cancer Biology, Institut d’Investigacio Biomedica de Bellvitge IDIBELL, Av. Gran Via n 199. 08907 - L’Hospitalet de Llobregat, Barcelona, Spain

*Author to whom correspondence should be addressed.


Front. Biosci. (Schol Ed) 2015, 7(1), 46–57;
Published: 1 June 2015

Technological breakthroughs are emphasizing the impact of epigenetic mechanisms in human health highlighting the importance of a fine-tune orchestration of DNA methylation, micro RNAs, histone modifications, and chromatin structure. Transcriptional regulators sense the concentration of intermediary metabolites associated to a wide variety of biological processes including the long-term imprinting and heritable DNA methylation. Recent epigenetic mechanisms associated with cholesterol and lipid homeostasis have a critical impact in the susceptibility, development and progression of complex diseases such as type 2 diabetes mellitus, non-alcoholic fatty liver, obesity and metabolic syndrome. The heritability of epigenetic states emerge as an additional level of complexity where the extension of somatic as well as inherited epigenetic modifications may require a thoughtful reconsideration in many human diseases related with metabolic disorders.

Transgenerational Inheritance
Transcriptional Regulation
Lipid Homeostasis
Fatty Liver
DNA methylation
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