IMR Press / FBS / Volume 4 / Issue 1 / DOI: 10.2741/s262

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

Tissue specificities of tumor induction by aromatic amines

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1 Department of Urology, SUNY Upstate Medical University, Syracuse, NY 13210
2 Department of Chemical Carcinogenesis, Michigan Cancer Foundation, Detroit, Michigan 48201

*Author to whom correspondence should be addressed.

 

Front. Biosci. (Schol Ed) 2012, 4(1), 206–215; https://doi.org/10.2741/s262
Published: 1 January 2012
Abstract

Certain aryl compounds that have nitrogen substitutions on their ring structures are, following metabolic conversion to reactive derivatives, able to elicit toxic responses by virtue of their modifications of protein and nucleic acid. This group of compounds is often referred to as aromatic amines (AA), although from a structural perspective, compounds that can be converted metabolically to crucial AA derivatives are also capable of producing the same adverse biological effects. These effects include cellular death, mutagenic events and tumor induction. Importantly, in humans, AA can induce tumors in the urinary tract, and possibly other tissues. This contribution addresses the mechanisms by which AA are likely to produce these carcinogenic consequences.

Keywords
Carcinogenesis of Aromatic Amine
Metabolic Activation
Tissue Specificity
Cytosolic Acyltransferases
Cytosolic Sulfotransferase
Microsomal Acyltransferases
Cyclooxygenases
Review
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