Dengue is potentially a life-threatening arthropod-borne viral infection for which there are no known therapeutic agents till date. Early stage diagnosis of dengue infection is still lacking. Diagnosis is only made after severe manifestations and later stages of infection. Timely prognosis can prevent dengue related mortalities. The nucleic acid-based therapy has potential to emerge as a promising approach for early diagnosis and treatment of this viral infection. Many studies have been carried out suggested the regulatory role of ncRNAs thereby revealing the importance of protein-RNA and RNA-RNA interactions during infection. Various regulatory RNAs are either expressed by mammalian cells or generated by viral RNA have reported to play important roles in viral life cycle including dengue virus. Thus exploring host-virus interaction will pave the novel path for understanding the pathophysiology of febrile infection in dengue. Rapid advances in sequencing techniques along with significant developments in the field of RNA studies has made RNA therapeutics as one of the promising approaches as antiviral targets. The idea of RNA based therapies has been greatly backed by a Hepatitis C virus drug, Miravirsen which has successfully completed phase II clinical trial. In the present review, we will discuss the implications of different non-coding RNAs in dengue infection. Differential expression of small ncRNA may serve as a reliable biomarker of disease severity during different stages of infection and can also play regulatory roles in disease progression.
Cite this article
Role of non-coding RNAs in Dengue virus-host interaction
Deeksha Madhry1, Kush Kumar Pandey1, Jaskaran Kaur2, Yogita Rawat2, Leena Sapra1, Ravi Kumar Y.S.3, Rupesh K. Srivastava1, Sankar Bhattacharyya2, Bhupendra Verma1,*
1 Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, 110029 New Delhi, India
2 Translational Health Science and Technology Institute NCR Biotech Science Cluster, 121001 Faridabad, India
3 Department of Biotechnology, M. S. Ramaiah Institute of Technology, MSR Nagar, 560054 Bengaluru, India
*Correspondence: email@example.com (Bhupendra Verma)
Front. Biosci. (Schol Ed) 2021, 13(1), 44–55; https://doi.org/10.52586/S552
Submitted: 26 September 2020 | Accepted: 25 November 2020 | Published: 30 June 2021
(This article belongs to the Special Issue Immunity and inflammation in health and disease)
Copyright: © 2021 The Author(s). Published by BRI.
This is an open access article under the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
Small non coding RNA