Dear Colleagues,

As a cellular degradation process, autophagy is responsible for elimination of either superfluous cytoplasmic materials, including misfolded proteins and aggregates, or damaged organelles. Although autophagy is considered a non-selective bulk-degradation process under starvation conditions, recent evidence shows that autophagy can remove specific cargos under various pathological conditions. For example, damaged organelles such as mitochondria (mitophagy), ER (ER-phagy), peroxisome (pexophagy), lysosome (lysophagy), melanosome (melanophagy), and stress granule (granulophagy) can be removed by selective autophagy process. Dysregulation in the removal of protein aggregates, damaged organelles, or intracellular pathogens leads to various human diseases. Thus, the regulation of autophagy has emerged as a crucial therapeutic strategy for various human diseases, including neurodegenerative diseases, cancer, and the aging process. This special issue will cover reviews and research articles on the topic "Molecular Mechanism and Therapeutics for Selective Autophagy".

Prof. Dr. Dong-Hyung Cho
Guest Editor