Dear Colleagues,

Retinal degenerative diseases, including age-related macular degeneration and inherited retinopathies, represent a major cause of irreversible vision loss. These complex disorders arise from multifactorial molecular alterations involving oxidative stress, mitochondrial dysfunction, chronic inflammation, and dysregulation of cell death pathways. Recent advances in multi-omics technologies and systems biology have opened new avenues for deciphering the intricate networks underlying retinal degeneration.

This Special Issue aims to gather high-quality original research articles, reviews, and perspectives focusing on systems-level insights into the molecular and functional mechanisms driving retinal degeneration. Topics of interest include, but are not limited to: transcriptomics, proteomics, and metabolomics approaches; the role of non-coding RNAs; epigenetic regulation; and cell-cell and immune interactions in the retinal microenvironment.

By unifying molecular pathways with functional outcomes, this Special Issue seeks to promote an integrated understanding of retinal degeneration, fostering the development of effective strategies for early diagnosis, prevention, and treatment.

We invite submissions from researchers across disciplines that intersect vision science, neurobiology, bioinformatics, and translational medicine.

Luigi Donato
Guest Editor