Dear Colleagues,

Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors with increasing incidence and prevalence, mainly arising in the gastroenteropancreatic tract, but also in the lung, pituitary (Pit-NET) and other organs. Frequent expression on cell surfaces of somatostatin receptors is peculiar in NENs and represents a target for therapy (i.e., somatostatin analogues and peptide-receptor radionuclide therapy). The heterogeneity of NENs is evident in both biological and clinical characteristics. Accordingly, they require a multidisciplinary approach for clinical management while a better insight of pathogenetic mechanisms is needed. In recent years, specialists and researchers from diverse fields have collaborated, striving to enhance the understanding of NENs biology. This collective effort has resulted in the development and diversification of therapeutic approaches for these conditions. Many ongoing studies are expected to further improve our understanding of the biology of NENs along with treatment and diagnosis.

This special issue for Frontiers in Bioscience-Landmark aims to gather research on biological insights and innovations for enhancing NENs patients management. We welcome reviews on cutting edge and original papers exploring recent epigenetic mechanisms in Pit-NETs and NEN pathology. Of special interest are new insights into miRNAs mechanisms of action underlying pathological processes of Pit-NETs and NEN, miRNA-associated therapeutic target discovery, miRNA-associated RNA-based therapy (including miRNAs delivery systems), miRNA biomarkers (including circulating miRNAs), and miRNAs in cell-to-cell communication.

Dr. Roberta Modica and Dr. Claudia Pivonello
Guest Editors