Dear Colleagues,

Membrane proteins mediate a wide range of processes that are critical and fundamental for the survival of cells. In fact, membrane proteins play many roles in biological membranes because of their involvement in cell physiology, cellular homeostasis, metabolism and signaling. They are also involved in the translocation of many classes of metabolites such as sugars, amino acids, lipids, vitamins, inorganic ions and others, and in mediating communication between the cell and the environment. Membrane proteins include transporters, channels, receptors, enzymes and many other types, making them indispensable for biological pathways. A large number of membrane proteins have been identified and functional and biological studies performed on them over the years using both in vitro and in vivo systems. The solved structures of many of these proteins have paved the way for further investigations. Furthermore, alterations in membrane protein functions, often due to genetic mutations, are responsible for several diseases. Hence, the purpose of this Special Issue “Membrane proteins: new insights into structure, metabolic functions and mutations " is to integrate current knowledge on the physiological roles, mechanisms and function of a wide range of membrane proteins. This will highlight the changes in expression, activity and structure of membrane proteins as they relate to different groups of diseases.

Research papers and review manuscripts with a special focus on membrane proteins are very welcome. Short communications will also be considered.

Dr. Daniela Valeria Miniero

Guest Editor