IMR Press / FBL / Volume 27 / Issue 1 / DOI: 10.31083/j.fbl2701028
Open Access Original Research
A rhodamine derivative probe for highly selective detection of Cu(II)
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1 College of Life Science and Chemistry, Beijing Key Laboratory of Environmental and Oncology, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China

Academic Editors: Guohui Sun and Anna Lewinska

Front. Biosci. (Landmark Ed) 2022, 27(1), 28;
Submitted: 18 May 2021 | Revised: 5 July 2021 | Accepted: 16 July 2021 | Published: 18 January 2022
(This article belongs to the Special Issue Recent Advances in Cancer Research and Environmental Toxicology)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.

Background: Abnormal Cu(II) ions levels may affect many biological functions, and it is of great importance to detect Cu(II) ions in organisms. Methods: Herein, we report a near-infrared (NIR) fluorescent probe EtRh-N-NH𝟐 for the detection of Cu(II). In the probe structure, a rhodamine core was used, and a hydrazine group was employed as the responsive site. Results & Conlusions: EtRh-N-NH𝟐 displayed sensitive, specific and fast response upon Cu(II) with excellent linear relationship between the concentration and fluorescence emission intensity in 0–1 μM range. The releasing EtRh-COOH exhibited 762 nm of emission wavelength with a 75 nm of Stokes shift.

Large Stokes shift
Cu(II) detection
Fluorescent probe
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