A rhodamine derivative probe for highly selective detection of Cu(II)

¹ College of Life Science and Chemistry, Beijing Key Laboratory of Environmental and Oncology, Faculty of Environment and Life, Beijing University of Technology, 100124 Beijing, China

^*Correspondence: mo@bjut.edu.cn (Shanyan Mo)
Academic Editor: Anna Lewinska

Front. Biosci. (Landmark Ed) 2022, 27(1), 28; https://doi.org/10.31083/j.fbl2701028

Submitted: 18 May 2021 | Revised: 5 July 2021 | Accepted: 16 July 2021 | Published: 18 January 2022

(This article belongs to the Special Issue Recent Advances in Cancer Research and Environmental Toxicology)

This is an open access article under the CC BY 4.0 license.

Abstract

Background: Abnormal Cu(II) ions levels may affect many biological functions, and it is of great importance to detect Cu(II) ions in organisms. Methods: Herein, we report a near-infrared (NIR) fluorescent probe EtRh-N-NH ${}_{\bm{2}}$ for the detection of Cu(II). In the probe structure, a rhodamine core was used, and a hydrazine group was employed as the responsive site. Results & Conlusions: EtRh-N-NH ${}_{\bm{2}}$ displayed sensitive, specific and fast response upon Cu(II) with excellent linear relationship between the concentration and fluorescence emission intensity in 0–1 $\mu{}$ M range. The releasing EtRh-COOH exhibited 762 nm of emission wavelength with a 75 nm of Stokes shift.