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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Volume 13 Issue 2 2008
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- Open Access ArticleMolecular imaging of human epidermal growth factor receptor 2 (HER-2) expressionGang Niu, Weibo Cai, Xiaoyuan ChenFront. Biosci. (Landmark Ed) 2008, 13(2), 790–805; https://doi.org/10.2741/2720(This article belongs to the Special Issue Molecular imaging of biomarkers)7Download22Citations9Views
- Open Access ArticleDevelopment of Alzheimer's disease imaging agents for clinical studiesEun Kyoung Ryu, Xiaoyuan ChenFront. Biosci. (Landmark Ed) 2008, 13(2), 777–789; https://doi.org/10.2741/2719(This article belongs to the Special Issue Molecular imaging of biomarkers)4Download17Citations5Views
- Open Access ArticleRole of Rho GTPases in breast cancerYong Tang, Lola Olufemi, Man-Tzu Wang, Daotai NieFront. Biosci. (Landmark Ed) 2008, 13(2), 759–776; https://doi.org/10.2741/2718(This article belongs to the Special Issue Pathogenesis of tumor progression in breast and prostate cancer)20Download86Citations19Views
- Open Access ArticleMSPL/TMPRSS13Hiroshi Kido, Yuushi OkumuraFront. Biosci. (Landmark Ed) 2008, 13(2), 754–758; https://doi.org/10.2741/271735Download20Citations13Views
- Open Access ArticleNon-proteolytic activation of prorenin: activation by (pro)renin receptor and its inhibition by a prorenin prosegment, "decoy peptide"M Nasir Uddin, A H M Nurun Nabi, Tsutomu Nakagawa, Atsuhiro Ichihara, ... Fumiaki SuzukiFront. Biosci. (Landmark Ed) 2008, 13(2), 745–753; https://doi.org/10.2741/2716(This article belongs to the Special Issue Renin, prorenin, and prorenin receptor)3Download9Citations6Views
- Open Access ArticleTargeted gene modification by oligonucleotides and small DNA fragments in eukaryotesTakayuki SuzukiFront. Biosci. (Landmark Ed) 2008, 13(2), 737–744; https://doi.org/10.2741/2715(This article belongs to the Special Issue Targeted gene repair)4Download8Citations9Views
- Open Access ArticleThe autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapyJohn J. Shacka, Kevin A. Roth, Jianhua ZhangFront. Biosci. (Landmark Ed) 2008, 13(2), 718–736; https://doi.org/10.2741/2714(This article belongs to the Special Issue Molecular biology of neurodegeneration)31Download94Citations35Views
- Open Access Article
Neuroinflammation in Parkinson's disease: Is there sufficient evidence for mechanism-based interventional therapy?
Malú G. Tansey, Tamy C. Frank-Cannon, Melissa K. McCoy, Jae Kyung Lee, ... Thi A. TranFront. Biosci. (Landmark Ed) 2008, 13(2), 709–717; https://doi.org/10.2741/2713(This article belongs to the Special Issue Molecular biology of neurodegeneration)9Download79Citations17Views - Open Access ArticleClassification algorithms for phenotype prediction in genomics and proteomicsHabtom W. Ressom, Rency S. Varghese, Zhen Zhang, Jianhua Xuan, Robert ClarkeFront. Biosci. (Landmark Ed) 2008, 13(2), 691–708; https://doi.org/10.2741/2712(This article belongs to the Special Issue Classification and prediction in genomics and proteomics)16Download37Citations7Views
- Open Access ArticleEmergent unsupervised clustering paradigms with potential application to bioinformaticsDavid J. Miller, Yue Wang, George KesidisFront. Biosci. (Landmark Ed) 2008, 13(2), 677–690; https://doi.org/10.2741/2711(This article belongs to the Special Issue Classification and prediction in genomics and proteomics)5Download18Citations6Views
- Open Access ArticleDiverse roles of Rho family GTPases in neuronal development, survival, and deathDaniel A. Linseman, Frances Alexandra LoucksFront. Biosci. (Landmark Ed) 2008, 13(2), 657–676; https://doi.org/10.2741/2710(This article belongs to the Special Issue Molecular biology of neurodegeneration)13Download101Citations21Views
- Open Access Article
Quantitative flow cytometric monitoring of invasion of epithelial cells by Mycobacterium tuberculosis
Julie A. Chapeton-Montes, David F. Plaza, Carlos A. Barrero, Manuel A. PatarroyoFront. Biosci. (Landmark Ed) 2008, 13(2), 650–656; https://doi.org/10.2741/270913Download18Citations18Views - Open Access ArticleLong-term consequences of maternal smoking and developmental chronic nicotine exposureUrsula H. Winzer-SerhanFront. Biosci. (Landmark Ed) 2008, 13(2), 636–649; https://doi.org/10.2741/2708(This article belongs to the Special Issue Nicotinic acetylcholine receptors in adult and developing brain)18Download69Citations64Views
- Open Access ArticleZymogen activation, inhibition, and ectodomain shedding of matriptaseChen-Yong Lin, I-Chu Tseng, Feng-Pai Chou, Sheng-Fang Su, ... Robert B. DicksonFront. Biosci. (Landmark Ed) 2008, 13(2), 621–635; https://doi.org/10.2741/270733Download63Citations30Views
- Open Access ArticleHIV-1 vaccine development: tackling virus diversity with a multi-envelope cocktailJulia L Hurwitz, Xiaoyan Zhan, Scott A Brown, Mattia Bonsignori, ... Karen S SlobodFront. Biosci. (Landmark Ed) 2008, 13(2), 609–620; https://doi.org/10.2741/2706(This article belongs to the Special Issue Harnessing immune potential by vaccination)1Download17Citations6Views
- Open Access ArticleInterferon-inducible IFI16 protein in human cancers and autoimmune diseasesDivaker Choubey, Ranjan Deka, Shuk-mei HoFront. Biosci. (Landmark Ed) 2008, 13(2), 598–608; https://doi.org/10.2741/2705(This article belongs to the Special Issue ADAMTS-18: A metalloproteinase with multiple functions)34Download58Citations24Views
- Open Access ArticleNuclear diacylglycerol kinases: regulation and rolesDaniel M. Raben, Becky Tu-SekineFront. Biosci. (Landmark Ed) 2008, 13(2), 590–597; https://doi.org/10.2741/2704(This article belongs to the Special Issue Nuclear phosphoinositol lipids signaling)16Download25Citations4Views
- Open Access ArticleTWEAKing renal injuryAna Belen Sanz, Juan Antonio Moreno, Maria Dolores Sanchez-Nino, Alvaro C Ucero, ... Alberto OrtizFront. Biosci. (Landmark Ed) 2008, 13(2), 580–589; https://doi.org/10.2741/2703(This article belongs to the Special Issue TWEAK and FN14 in health and disease)7Download9Citations13Views
- Open Access Article
The type II transmembrane serine protease Matriptase-2 – identification, structural features, enzymology, expression pattern and potential roles
Andrew J. Ramsay, Janet C. Reid, Gloria Velasco, James P. Quigley, John D. HooperFront. Biosci. (Landmark Ed) 2008, 13(2), 569–579; https://doi.org/10.2741/270217Download34Citations30Views - Open Access Article
Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells
Rajesh L. Thangapazham, Anoop K. Singh, Pankaj Seth, Namita Misra, ... Radha K. MaheshwariFront. Biosci. (Landmark Ed) 2008, 13(2), 561–568; https://doi.org/10.2741/2701(This article belongs to the Special Issue Cancer chemoprevention - 2)4Download11Citations3Views - Open Access Article
The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis
Constanze Bonifer, David A. HumeFront. Biosci. (Landmark Ed) 2008, 13(2), 549–560; https://doi.org/10.2741/2700(This article belongs to the Special Issue Biology of the macrophage in human disease)46Download56Citations28Views - Open Access ArticleNuclear phosphoinositide signalingKeqiang Ye, Jee-Yin AhnFront. Biosci. (Landmark Ed) 2008, 13(2), 540–548; https://doi.org/10.2741/2699(This article belongs to the Special Issue Nuclear phosphoinositol lipids signaling)3Download21Citations3Views
- Open Access ArticleMT-SP1 proteolysis and regulation of cell-microenvironment interactionsMolly R Darragh, Ami S Bhatt, Charles S CraikFront. Biosci. (Landmark Ed) 2008, 13(2), 528–539; https://doi.org/10.2741/269825Download33Citations10Views
- Open Access ArticleClinical approaches in the treatment of Duchenne muscular dystrophy (DMD) using oligonucleotidesCarmen BertoniFront. Biosci. (Landmark Ed) 2008, 13(2), 517–527; https://doi.org/10.2741/2697(This article belongs to the Special Issue Targeted gene repair)6Download24Citations10Views
- Open Access ArticleGender differences in tobacco smoking dynamics and the neuropharmacological actions of nicotineJames R. PaulyFront. Biosci. (Landmark Ed) 2008, 13(2), 505–516; https://doi.org/10.2741/2696(This article belongs to the Special Issue Nicotinic acetylcholine receptors in adult and developing brain)20Download47Citations18Views
- Open Access Article
Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease
Marina R. Picciotto, Michele ZoliFront. Biosci. (Landmark Ed) 2008, 13(2), 492–504; https://doi.org/10.2741/269519Download157Citations56Views - Open Access ArticleNaturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and miceJerry A. StitzelFront. Biosci. (Landmark Ed) 2008, 13(2), 477–491; https://doi.org/10.2741/2694(This article belongs to the Special Issue Nicotinic acetylcholine receptors in adult and developing brain)2Download17Citations2Views
- Open Access ArticleNew insights into the molecular basis of mammalian sperm-egg membrane interactionsUlyana Vjugina, Janice P. EvansFront. Biosci. (Landmark Ed) 2008, 13(2), 462–476; https://doi.org/10.2741/2693(This article belongs to the Special Issue Sperm biology, from basic to clinic)26Download56Citations22Views
- Open Access ArticleMacrophage activation and polarizationFernando Oneissi Martinez, Antonio Sica, Alberto Mantovani, Massimo LocatiFront. Biosci. (Landmark Ed) 2008, 13(2), 453–461; https://doi.org/10.2741/2692(This article belongs to the Special Issue Lipopolysaccharide signaling and induction of gene expression in monocytes)1174Download2065Citations695Views
- Open Access ArticleEGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancerSharmila Shankar, Suthakar Ganapathy, Sunil R. Hingorani, Rakesh K. SrivastavaFront. Biosci. (Landmark Ed) 2008, 13(2), 440–452; https://doi.org/10.2741/2691(This article belongs to the Special Issue Cancer chemoprevention - 2)60Download183Citations149Views
- Open Access ArticleRole of P2Y receptor subtypes in platelet-derived microparticle generationBryan N. Kahner, Robert T. Dorsam, Satya P. KunapuliFront. Biosci. (Landmark Ed) 2008, 13(2), 433–439; https://doi.org/10.2741/2690(This article belongs to the Special Issue Platelet physiology)9Download21Citations7Views
- Open Access ArticleEffects of exercise training upon endothelial function in patients with cardiovascular diseaseAxel Linke, Sandra Erbs, Rainer HambrechtFront. Biosci. (Landmark Ed) 2008, 13(2), 424–432; https://doi.org/10.2741/2689(This article belongs to the Special Issue Exercise in medicine: from basic science to clinical practice)29Download48Citations68Views
- Open Access ArticleMolecular pathophysiology and physical chemistry of cholesterol gallstonesHelen H. Wang, Piero Portincasa, David Q.-H. WangFront. Biosci. (Landmark Ed) 2008, 13(2), 401–423; https://doi.org/10.2741/2688(This article belongs to the Special Issue Molecular basis of gallstone pathogenesis)37Download62Citations46Views