IMR Press / FBL / Volume 13 / Issue 2 / DOI: 10.2741/2700

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.


The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis

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1 University of Leeds, Leeds Institute of Molecular Medicine, St. James's University Hospital, Section of Experimental Haematology, The Wellcome Trust Brenner Building, Leeds LS9 7TF, United Kingdom
2 The Roslin Institute, University of Edinburgh, Roslin, Midlothian EH25 9PS, United Kingdom

Academic Editor: Angel Lee

Front. Biosci. (Landmark Ed) 2008, 13(2), 549–560;
Published: 1 January 2008
(This article belongs to the Special Issue Biology of the macrophage in human disease)

The colony-stimulating-factor 1 receptor (CSF-1 R) is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. Mice deficient for the csf1r gene show multiple defects in macrophage development, reproduction and tissue remodeling. Moreover, deregulation of this gene is a hallmark of many tumors. This includes repression of expression in acute myeloid leukemia and aberrant activation in certain solid tumors, such as breast cancer. Expression of this gene therefore needs to be tightly controlled. This review summarizes experiments providing a detailed picture of how transcription of csf1r gene expression is regulated. Aside from the direct relevance to hematopoiesis, studies of csf1r transcriptional regulation provide a model for understanding the molecular mechanisms that control mammalian cell fate.

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