IMR Press / FBL / Volume 13 / Issue 2 / DOI: 10.2741/2714

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy
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1 Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, University of Alabama at Birmingham, Birmingham, AL 35294
2 Department Veterans Affairs, Birmingham VA Medical Center, Birmingham, AL 35294

Academic Editor: Santosh R. D Mello

Front. Biosci. (Landmark Ed) 2008, 13(2), 718–736;
Published: 1 January 2008
(This article belongs to the Special Issue Molecular biology of neurodegeneration)

Alterations in the autophagy-lysosomal degradation pathway have been described in normal brain aging and in age-related neurodegenerative diseases including Alzheimer's (AD) and Parkinson's (PD). An improper clearance of proteins in AD and PD may result either from a compromise in the autophagy-lysosomal degradation pathway or induce alterations in this pathway, and may result in neuron dysfunction and neuron loss. This review provides an overview of AD and PD with a specific focus on macroautophagy, chaperone-mediated autophagy and lysosome function in human and experimental models of AD and PD. Potential therapies for AD and PD are also discussed that may promote survival by regulating the autophagy and lysosomal degradation pathway.

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