Dear Colleagues,

The clinical management of heart failure has evolved from a singular cardiac intervention approach to a systemic perspective that considers multi-organ interactions. This shift is driven by a deeper understanding of the complex dialogue between the heart and other organs. Whether the patient is in acute cardiogenic shock or chronic heart failure, cardiac dysfunction often leads to dysregulation of multiple organs such as the lungs, kidneys, and liver. These secondary organ injuries further exacerbate the cardiac burden, creating a vicious cycle. For instance, approximately 36% of patients with cardiogenic shock experience single-organ failure, and nearly half develop multiple-organ failure (MOF), significantly increasing in-hospital mortality rates. These pathophysiological processes involve mechanisms such as neurohormonal imbalance, inflammatory activation, and metabolic disorders, thereby necessitating interdisciplinary research to optimize therapeutic strategies.

This special issue, "Organ Interactions in Heart Failure: Physiology, Pathophysiology, and Therapeutics", will compile multidisciplinary research findings to facilitate the translation of mechanistic discoveries into clinical practice. We invite submissions in the following areas, including but not limited to: early diagnosis, risk stratification, organ support, therapeutic optimization, and interdisciplinary collaboration.

Dr. Guo-wei Tu, Ying Su and Ming-hao Luo
Guest Editors