International Journal of Pharmacology (IJP) is published by IMR Press from Volume 21 Issue 4 (2025). Previous articles were published by another publisher under the CC-BY licence, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement.
1 Department of Chemistry, Faculty of Science, Zagazig University, Egypt
2 Department of Chemistry, Faculty of Science, Benha University, Egypt
3 Department of Pharmaceutical Chemistry, Drug Exploration and Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
4 Department of Peptide Chemistry, Chemical Industries Research Division, National Research Centre, 12622, Dokki, Cairo, Egypt
Abstract
In order to obtain peptide based surface active agents with antimicrobial activity, a series of polyethylene glycol bounded peptide chains were synthesized (I-VI). The investigated peptide chains contain aliphatic and aromatic amino acids in different sequences. These compounds were prepared by use of liquid phase method loaded on polyethylene glycol with molecular weight 3000 Daltons as a polymeric support. The produced target peptides were characterized by means of their amino acid analysis, HPLC and UV spectroscopy. The physicochemical, surface active properties measurements and in vitro antimicrobial activity of the synthesized peptide chains were evaluated. The synthesized peptide chains were found to have promising surface properties beside their antimicrobial activity.
Keywords
- Peptide
- physicochemical properties
- surfactants
- antimicrobial
- liquid phase method
- biodegradability