IMR Press / FBS / Volume 2 / Issue 3 / DOI: 10.2741/S104

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Epigenetic aspects of the allergic diseases
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1 Department of Allergy, University Hospital of Salamanca, 37008 Salamanca, Spain
2 Department of Clinical Biochemistry, University Hospital of Salamanca, 37008 Salamanca, Spain
3 Department of Medicine, University of Salamanca, 37008 Salamanca, Spain

*Author to whom correspondence should be addressed.

Academic Editor: Ernesto Enrique

Front. Biosci. (Schol Ed) 2010, 2(3), 815–824;
Published: 1 June 2010
(This article belongs to the Special Issue New insights in diagnosis and treatment of allergic diseases)

Several studies have proven the important influence that environmental exposures have in the individual's susceptibility to suffer allergy and other related diseases, mostly during embryonic or early life. Although the relationship between the environment and allergic diseases had been previously reported, one interesting attempt to describe this relationship was Strachan's hygiene hypothesis, proposed almost two decades ago. Since then, several studies have identified new environmental factors related to an increased risk of allergic disease. In this context, epigenetic modifications appear as a possible link between the environment and genome, providing a plausible mechanism for explaining how the recent changes in lifestyle can modify gene expression, and thus, lead to a disease state. Here, we will focus on the environmental modifiers that have been described and the possible role of epigenetic modifications.

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