Dear Colleagues,

Transcriptional regulation is a critical biological process acting during cell response to a variety of signals, during development, and during lifetime to maintain cell identity and to coordinate cellular activity. This control occurs through multiple temporal and functional steps and involves numerous molecules including transcription factors, cofactors, and chromatin regulators. It is well established that many human diseases, including cancer, are characterized by global dysregulation of transcription since most of the signalling pathways ultimately target transcription machinery. Indeed, most of cancer types can be caused by mutations/alterations in regulatory sequences, transcription factors, splicing regulators, cofactors, chromatin regulators, ncRNAs, and other components of transcription apparatus.

Advances in our understanding of molecules and mechanisms involved in the transcriptional regulation may lead to novel insights into the pathogenetic mechanisms of various cancers thus providing novel diagnostic, prognostic, and therapeutic targets.

The aim of this Special Issue is to publish original research and comprehensive reviews on the recent advances in the field of molecular genetics and genomics, as well as omics studies exploring the effects of transcriptional dysregulation on human cancers.

Amelia Casamassimi, Ciro Abbondanza, Monica Rienzo and Erika Di Zazzo
Guest Editors