IMR Press / FBE / Volume 5 / Issue 2 / DOI: 10.2741/E657

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Hsp10: anatomic distribution, functions, and involvement in human disease

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1 Department of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, Italy
2 Istituto Euro-Mediterraneo di Scienza e Tecnologia (IEMEST), Palermo, Italy
3 Laboratory of Molecular Oncology, Department of Oncology, Military Institute of Medicine, Warsaw, Poland
4 Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy
5 Department of Neonatology and Neonatal Intensive Care, University of Palermo , Italy
6 Department of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore, and IMET, Baltimore, MD, USA

*Author to whom correspondence should be addressed.

Academic Editor: Anna Czarnecka

Front. Biosci. (Elite Ed) 2013, 5(2), 768–778; https://doi.org/10.2741/E657
Published: 1 January 2013
(This article belongs to the Special Issue Frontiers in molecular medicine)
Abstract

There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and secretory granules, alone or in combination with other proteins. In these extramitochondrial locales, Hsp10 plays an active role in cell signalling. For example, cancer cells often show altered levels of Hsp10, compared to normal cells. Hsp10 may also be found in the extracellular space and in the bloodstream, with a possible immunomodulatory activity. This minireview focuses on some studies to date on the involvement of Hsp10 in human disease pathogenesis.

Keywords
Heat shock proteins
Hsp10
Cpn10
Early pregnancy factor
Hsp60
Cancer
Autoimmune diseases
Review
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