IMR Press / FBE / Volume 13 / Issue 1 / DOI: 10.2741/872

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Cucumeropsis mannii reverses high-fat diet induced metabolic derangement and oxidative stress
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1 Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Clinical Sciences, College of Medicine, Lagos State University, Ikeja, Lagos State
2 Behavioral Neuroscience and Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
3 Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Chieti, Italy
4 Molecular Bacteriology Unit, Department of Microbiology and Parasitology, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria
5 Behavioral Neuroscience and Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun State, Nigeria
Send correspondence to: Adejoke Y Onaolapo, Behavioral Neuroscience and Neurobiology Unit, Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, Nigeria, Tel: 2348062240434, E-mail: adegbayibiy@yahoo.com
Front. Biosci. (Elite Ed) 2021, 13(1), 54–76; https://doi.org/10.2741/872
Published: 1 October 2020
Abstract

Cucumeropsis mannii (CM) belongs to the melon family and is native to West Africa. There is a paucity of information on its medicinal or nutraceutical potential. Here, we examined the impact of CM in mice that were treated with a normal or a high fat diet (HFD). The CM extracts had a high levels of phenols, flavonoids, ascorbic acid and significant antioxidant activity. Treatment of mice with a HFD diet, led to the memory impairment. However, mice on HFD and received CM, despite increased food intake, showed a decrease in the body weight, locomotion, rearing, grooming, acetylcholinesterase activity and γ-amino butyric acid levels and anxiolysis. Also CM induced a reversal of HFD–induced changes in glucose levels, lipid peroxidation and super-oxide dismutase activity. These data show that CM leads to variable behavioural, biochemical and metabolic effects depending on the diet of animals.

Keywords
Cucurbitaceae
dyslipidaemia
Nutrition
Melon
Neurobehavior
Phytochemistry
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