IMR Press / FBE / Volume 1 / Issue 1 / DOI: 10.2741/E27

Frontiers in Bioscience-Elite (FBE) is published by IMR Press from Volume 13 Issue 2 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

The role of free radicals in sepsis development
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1 Programa de Pos-Graduacao em Bioquimica, Departamento de Bioquimica, UFRGS, Brazil
2 Programa de Pos-Graduacao em Ciencias da Saude, Unidade Academica de Ciencias da Saude, UNESC, Brazil
Front. Biosci. (Elite Ed) 2009, 1(1), 277–287;
Published: 1 June 2009

Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. Several researchers have linked reactive oxygen species (ROS) and reactive nitrogen species (RNS) with the onset, progression and outcome of sepsis, both in pre-clinical and in clinical studies. ROS/RNS are important signaling molecules but its overproduction must be avoided by organism, otherwise oxidative stress takes place. Even so, the use of antioxidant as treatment in sepsis constitutes a challenge, with both null and encouraging results. In this review, it will be summarized the role of free radicals in the onset, progression and outcome of sepsis, as well as its participation in organ failure and cardiovascular collapse. Experimental treatments that may interfere in oxidative stress in sepsis will also be contemplated.

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