Dear Colleagues,

Cardiovascular and kidney diseases are tightly interconnected through complex hemodynamic, metabolic, and inflammatory pathways. The bidirectional relationship between the heart and kidneys, often described as the cardiorenal syndrome, significantly influences patient outcomes, particularly in heart failure, hypertension, diabetes, and chronic kidney disease. This special issue aims to provide a comprehensive overview of emerging insights into the mechanisms linking cardiovascular and renal dysfunction. Contributions will highlight the role of novel biomarkers in early detection and disease monitoring, strategies for risk stratification across diverse patient populations, and advances in therapeutic interventions ranging from pharmacological treatments to device-based and lifestyle approaches. By integrating perspectives from both cardiology and nephrology, this issue seeks to stimulate multidisciplinary dialogue, identify unmet needs, and guide future research to optimize care and improve outcomes in patients with overlapping cardiovascular and kidney disease.

Dr. Davide Bolignano
Guest Editor