IMR Press / RCM / Volume 23 / Issue 9 / DOI: 10.31083/j.rcm2309310
Open Access Review
Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury
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1 Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, 130021 Changchun, Jilin, China
2 Department of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, China
*Correspondence: l_w01@jlu.edu.cn (Wei Liu); wei_shixiong@163.com (Shixiong Wei)
These authors contributed equally.
Academic Editor: Vincenzo Lionetti
Rev. Cardiovasc. Med. 2022, 23(9), 310; https://doi.org/10.31083/j.rcm2309310
Submitted: 29 May 2022 | Revised: 3 July 2022 | Accepted: 19 July 2022 | Published: 13 September 2022
(This article belongs to the Special Issue Translational Perioperative Cardioprotection)
Copyright: © 2022 The Author(s). Published by IMR Press.
This is an open access article under the CC BY 4.0 license.
Abstract

Perioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos) is a novel cell-free therapeutic strategy and has significantly benefitted patients suffering from various diseases. In this review, we comprehensively analyzed the application of MSC-Exos to prevent myocardial infarction/injury by regulating inflammatory reactions, inhibiting cardiomyocyte apoptosis and autophagy, promoting angiogenesis, and mediating cardiac remodeling. Finally, we assessed the therapeutic effects and the challenges associated with the application of MSC-Exos from a clinical perspective.

Keywords
mesenchymal stem cell
exosomes
cardioprotection
myocardial injury
Funding
WA2020RW18/Development Center for Medical Science & Technology, National Health Commission of the People’s Republic of China
320.6750.19092-1/Wu Jieping Medical Foundation
20190701043GH/Jilin Province Scientific and Technological Department, International Scientific and Technological Cooperation Project
Figures
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