†These authors contributed equally.
Academic Editor: Wayne L. Miller
Background: Elevated left ventricular mass index contributes to
morbidity and mortality induced by heart failure and M2 macrophages play a
critical role in left ventricular remodeling. Here, our aim was to investigate
the roles of M2 macrophage-related genes in heart failure. Methods:
GSE10161 was downloaded and the abundance of immune cells were estimated utilizing the
CIBERSORT algorithm. Using the limma test and correlation analysis,
differentially expressed plasm B cells and M2 macrophages-related genes (DEBRGs
and DEMRGs) were documented. Functional pathways and the protein-protein
interaction network were analyzed and the hub DEMRGs were obtained. The hub
DEMRGs and their interactions were analyzed using NetworkAnalyst 3.0 and for
validation, the hub DEMRGs expressions were analyzed using the GSE135055,
GSE116250 and GSE74144 datasets. Results: 103 differentially expressed
genes were correlated with the abundance of M2 Macrophages and were identified as
DEMRGs (PCC