Dear Colleagues,
In recent years, significant progress has been made in the diagnosis and management of brain tumors. For example, new technologies such as intraoperative ultrasound, intraoperative magnetic resonance imaging (MRI), computed tomography (CT), laser interstitial thermal therapy (LITT), and awake surgery have revolutionized the overall survival and functional outcomes of patients with brain tumors. These advances have resulted in greater precision in tumor surgical resection and lower post-operative deficit.
Recent advances in genomics, transcriptomics, and epigenomics have shed needed light on mechanisms of tumor pathogenesis, and allowed refined classification of adult and pediatric brain tumor subtypes, as well as providing molecular information useful in treatment stratification. Moreover, novel genetic and epigenetic biomarkers have great promise in tailoring preventive care and disease prognosis. The use of novel gene therapy approaches may finally allow site-specific delivery of therapeutic molecules, using either viral or non-viral delivery vehicles, and have opened new horizons and opportunities in the field of neuroscience and neurosurgery.
In this Special Issue we will focus on articles in the field of neuroscience and neurosurgery that describe:
•    Intraoperative ultrasound
•    Intraoperative CT
•    Gene expression
•    Genetic variants
•    DNA methylation biomarkers
•    Non-coding RNA expression
•    Gene therapy

We welcome interested investigators to submit original papers, systematic reviews, or meta-analyses on these very interesting topics.

Dr.  Nicola Montemurro and Dr. Andrea Stoccoro
Guest Editors