Dear colleagues,
 
Research into the nervous system is currently experiencing one of its most exciting eras, with significant advances in the treatment of several neurological disorders. These advances are due to the development of complex experimental models over the past few decades. In addition, innovative methodologies and techniques have made it possible to evaluate the central nervous system, as well as interactions between the different types of constituent cells. Events related to signaling pathways implicated in different cellular and molecular aspects of several neurodegenerative disorders can also be studied with these novel techniques. 

Ischemic stroke has emerged as a priority research area due to its high worldwide incidence, the sequelae from this disease, and because there is still no effective therapy to allow recovery from the effects of hypoxia. Therefore, it is important to develop strategies for inducing neuronal recovery following ischemic stroke. This could in turn lead to functional improvements in ischemia-affected brain regions.  

This special issue of “Cyto-Neurology in Ischemia” aims to provide a summary of the latest advances in the field, with a special emphasis on the cellular and molecular mechanisms through which it may be possible to induce the recovery of neuronal cells and hence the deleterious effects of ischemia. We welcome original research articles and comprehensive reviews, especially those that further our current understanding of the molecular mechanisms involved in neuronal modulation.

Topic list: 
•    Prevention of neuronal death. 
•    Neuronal signaling pathways. 
•    Neurorepair.
•    Neuron–astrocyte interactions in ischemia. 
•    Prevention of neurodegeneration.
•    Neuronal metabolism.
•    Animal models of ischemia.
•    In vitro models of ischemia. 

Dr. Cláudio Roque and Dr. María C. Burguete

Guest Editors