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Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jan 2016Review

Chemical immobilization of antimicrobial peptides on biomaterial surfaces

Rafael R. Silva 1, Karen Y.P.S. Avelino 2, Kalline L. Ribeiro 1, Octavio L. Franco 3, Maria D.L. Oliveira 2, Cesar A.S. Andrade 1,2,*
Affiliations
Article Info

1 Programa de Pos-Graduacao em Inovacao Terapeutica, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brasil

2 Departamento de Bioquímica, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brasil

3 Centro de Analise Proteomicas e Bioquimicas de Brasilia, Universidade Catolica de Brasília, 71966-700, Brasilia, DF, Brasil

*Author to whom correspondence should be addressed.

 

Abstract

Hospital infections associated with surgical procedures and implants still present a severe problem in modern societies. Therefore, new strategies to combat bacterial infections mainly caused by microorganisms resistant to conventional antibiotics are necessary. In this context, antimicrobial peptides have gained prominence due to their biocompatibility, low toxicity and effectiveness. The immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces is an excellent alternative for the development of new biodevices with microbicidal properties. Herein, we describe reports related to physical-chemical characterization, in vitro/in vivo studies and the clinical applicability of such active surfaces. In this review, we focused on the mechanisms of action, different peptide immobilization strategies on solid surfaces and the microbicidal effectiveness of AMPs.

Keywords

  • Antimicrobial peptides
  • Immobilization
  • Surface
  • Biomaterial
  • Review

References