Information
References
Contents
Download
[1]Pizarro, J.G. Folch, J. Vazquez De la Torre, A. Verdaguer, E. Junyent, F. Jordán, J. Pallas, M. Camins, A: Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line. Free Radic Res 43, 985–994 (2009)
[2]Sriram C.S. Jangra, A. Kasala, E.R. Bodduluru, L.N. Bezbaruah B.K: Targeting poly(ADP-ribose) polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation. Neurochem Int 76, 70-81 (2014)
[3]Formentini, L. Macchiarulo, A. Cipriani, G. Camaioni, E. Rapizzi, E. Pellicciari, R. Moroni, F. Chiarugi, A: Poly (ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. J Biol Chem 284, 17668–17676 (2009)
[4]Berger, N. Sims, J. Catino, D. Berger, S: Poly (ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells. Princess Takamatsu Symp 13, 219–226 (1983)
[5]Sriram, C.S. Jangra A. Gurjar, S.S. Hussain, M.I. Borah, P. Lahkar, M. Mohan, P. Bezbaruah, B.K: Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice. Pharmacol Biochem Behav 133, 83-91 (2015)
[6]Sriram C.S. Jangra, A. Madhana, R.M. Gurjar, S.S. Mohan, P. Bezbaruah, B.K: Multiple facets of poly(ADP-ribose) polymerase-1 in n eurological diseases. Neural Regen Res 10(1), 49–51 (2015)
[7]Liu, J.F. Konstantinopoulos, P.A., Matulonis, U.A. PARP inhibitors in ovarian cancer: current status and future promise. Gynecol Oncol 133(2), 362-369 (2014)
[8]Mabley, J.G. Wallace, R. Pacher, P. Murphy, K. Szabó, C: Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. Int J Mol Med 19(6), 947-52 (2007)
[9]Ihnat, M.A. Thorpe, J.E. Kamat, C.D. Szabó, C. Green, D.E. Warnke, L.A. Lacza, Z. Cselenyák, A. Ross, K. Shakir, S. Piconi, L. Kaltreider, R.C. Ceriello, A. Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling. Diabetologia 50(7), 1523-31 (2007)
[10]Jangra, A. Datusalia, A.K. Sharma, S.S: Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway. Pharmacol Biochem Behav 114-115, 43-51 (2013)
[11]Jeil Pharmaceutical Co., Ltd: The evaluation of safety, tolerability and pharmacokinetics of stroke targeting drug in healthy volunteers (JPI-289) In: ClinicalTrials.gov (Internet), National Library of Medicine (US), Bethesda, MD (cited 2014 May 15) Available from:
[12]Xie, L. Tiong, C.X. Bian, J.S. Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress. Am J Physiol Cell Physiol 303(1), C81-91 (2012)
[13]Saunders, F.D. Westphal, M. Enkhbaatar, P. Wang, J. Pazdrak, K. Nakano, Y. Hamahata, A. Jonkam, C.C. Lange, M. Connelly, R.L. Kulp, G.A. Cox, R.A. Hawkins, H.K. Schmalstieg, F.C. Horvath, E. Szabo, C. Traber, L.D. Whorton, E. Herndon, D.N. Traber, D.L: Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury. Am J Physiol Lung Cell Mol Physiol 298(3), L427-36 (2010)
[14]Soriano, F.G. Lorigados, C.B. Pacher, P. Szabó, C: Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis. Shock 35(6), 560-6 (2011)
[15]Jangra, A. Datusalia, A.K. Sharma, S.S: Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor. Neurol Res 36(7), 619-26 (2014)
[16]Shirai, H. Poetsch, A.R. Gunji, A. Maeda, D. Fujimori, H. Fujihara, H. Yoshida, T. Ogino, H. Masutani, M: PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways. Cell Death Dis 6, 4:e656 (2013)
[17]Nakadate, Y. Kodera, Y. Kitamura, Y. Tachibana, T. Tamura, T. Koizumi, F: Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint. Biochem Biophys Res Commun 29, 441 (4): 793-8 (2013)
[18]Feng, X. Koh, D.W: Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP- ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells. Int J Oncol 42(2), 749-56 (2013)
[19]Murai, J. Shar-yin, N.H. Das, B.B. Renaud, A. Zhang, Y. Doroshow, J.H. Ji, J. Takeda, S. Pommier, Y: Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res 72, 5588–5599 (2012)
[20]Kirsanov, K.I. Kotova, E. Makhov, P. Golovine, K. Lesovaya, E.A. Kolenko, V.M. Yakubovskaya, M.G. Tulin, A.V: Minor grove binding ligands disrupt PARP-1 activation pathways. Oncotarget 30;5(2):428-37 (2014)
[21]Okuda, H. Nishida, K. Higashi, Y. Nagasawa, K: NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci 19, 92(13):808-14 (2013)
[22]Bai, P. Cantó, C. Oudart, H. Brunyánszki, A. Cen, Y. Thomas, C. Yamamoto, H. Huber, A. Kiss, B. Houtkooper, R.H. Schoonjans, K. Schreiber, V. Sauve, A.A. Menissier-de Murcia, J. Auwerx, J: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab 13(4), 461-8 (2011)
[23]Chung, H.T. Joe, Y. Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases. Integr med res in press (2014)
[24]Mabley, J.G. Horváth, E.M. Murthy, K.G. Zsengellér, Z. Vaslin, A. Benko, R. Kollai., M. Szabó, C: Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. J Pharmacol Exp Ther 315(2), 812-20 (2005)
[25]Mahrouf-Yorgov, M. Marie, N. Borderie, D. Djelidi, R. Bonnefont-Rousselot, D. Legrand, A. Beaudeux, J.L. Peynet, J: Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells. Metabolism 58(4), 525-33 (2009)
Article Metrics
Download
- Contents
Information
Download
Contents
Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Alternative mechanisms of inhibiting activity of poly (ADP-ribose) polymerase-1
, Ashok Jangra 1, Babul Kumar Bezbaruah 1,2, Athira K.V. 1, Shivaji Sykam 31 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Narkachal Hilltop, Bhangagarh, Guwahati, Assam, India, PIN 78103
2 Department of Pharmacology, Gauhati Medical College, Narkachal Hilltop, Bhangagarh, Guwahati, Assam, India
3 IMS Health, Mumbai, Maharashtra, India
*Author to whom correspondence should be addressed.
Abstract
Poly ADP-ribose polymerase (PARP-1), a DNA nick-sensor enzyme, is an abundant nuclear protein. Upon sensing DNA breaks, PARP-1 gets activated and cleaves NAD into nicotinamide and ADP-ribose and polymerizes the latter onto nuclear acceptor proteins including histones, transcription factors, and PARP-1 itself. Poly(ADP-ribosylation) mainly contributes to DNA repairing mechanism. However, oxidative stress-induced over-activation of PARP-1 consumes excess of NAD and consequently ATP, culminating into cell necrosis. This cellular suicide pathway has been implicated in several conditions such as stroke, myocardial ischemia, diabetes. Thus, it can be a rationale approach to inhibit the activity of PARP-1 for reducing detrimental effects associated with oxidative stress-induced over-activation of PARP-1. Several preclinical as well as clinical studies of PARP-1 inhibitors have been used in conditions such as cancer, stroke and traumatic brain injury. Conventionally, there are many studies which employed the concept of direct inhibition of PARP-1 by competing with NAD. Here, in the present review, we highlight several prospective alternative approaches for the inhibition of PARP-1 activity.
Keywords
- PARP-1
- DNA
- Stress
- Inflammation
- Review
References
- [1] Pizarro, J.G. Folch, J. Vazquez De la Torre, A. Verdaguer, E. Junyent, F. Jordán, J. Pallas, M. Camins, A: Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line. Free Radic Res 43, 985–994 (2009)
- [2] Sriram C.S. Jangra, A. Kasala, E.R. Bodduluru, L.N. Bezbaruah B.K: Targeting poly(ADP-ribose) polymerase1 in neurological diseases: A promising trove for new pharmacological interventions to enter clinical translation. Neurochem Int 76, 70-81 (2014)
- [3] Formentini, L. Macchiarulo, A. Cipriani, G. Camaioni, E. Rapizzi, E. Pellicciari, R. Moroni, F. Chiarugi, A: Poly (ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. J Biol Chem 284, 17668–17676 (2009)
- [4] Berger, N. Sims, J. Catino, D. Berger, S: Poly (ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells. Princess Takamatsu Symp 13, 219–226 (1983)
- [5] Sriram, C.S. Jangra A. Gurjar, S.S. Hussain, M.I. Borah, P. Lahkar, M. Mohan, P. Bezbaruah, B.K: Poly (ADP-ribose) polymerase-1 inhibitor, 3-aminobenzamide pretreatment ameliorates lipopolysaccharide-induced neurobehavioral and neurochemical anomalies in mice. Pharmacol Biochem Behav 133, 83-91 (2015)
- [6] Sriram C.S. Jangra, A. Madhana, R.M. Gurjar, S.S. Mohan, P. Bezbaruah, B.K: Multiple facets of poly(ADP-ribose) polymerase-1 in n eurological diseases. Neural Regen Res 10(1), 49–51 (2015)
- [7] Liu, J.F. Konstantinopoulos, P.A., Matulonis, U.A. PARP inhibitors in ovarian cancer: current status and future promise. Gynecol Oncol 133(2), 362-369 (2014)
- [8] Mabley, J.G. Wallace, R. Pacher, P. Murphy, K. Szabó, C: Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D. Int J Mol Med 19(6), 947-52 (2007)
- [9] Ihnat, M.A. Thorpe, J.E. Kamat, C.D. Szabó, C. Green, D.E. Warnke, L.A. Lacza, Z. Cselenyák, A. Ross, K. Shakir, S. Piconi, L. Kaltreider, R.C. Ceriello, A. Reactive oxygen species mediate a cellular ‘memory’ of high glucose stress signalling. Diabetologia 50(7), 1523-31 (2007)
- [10] Jangra, A. Datusalia, A.K. Sharma, S.S: Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway. Pharmacol Biochem Behav 114-115, 43-51 (2013)
- [11] Jeil Pharmaceutical Co., Ltd: The evaluation of safety, tolerability and pharmacokinetics of stroke targeting drug in healthy volunteers (JPI-289) In: ClinicalTrials.gov (Internet), National Library of Medicine (US), Bethesda, MD (cited 2014 May 15) Available from:
- [12] Xie, L. Tiong, C.X. Bian, J.S. Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress. Am J Physiol Cell Physiol 303(1), C81-91 (2012)
- [13] Saunders, F.D. Westphal, M. Enkhbaatar, P. Wang, J. Pazdrak, K. Nakano, Y. Hamahata, A. Jonkam, C.C. Lange, M. Connelly, R.L. Kulp, G.A. Cox, R.A. Hawkins, H.K. Schmalstieg, F.C. Horvath, E. Szabo, C. Traber, L.D. Whorton, E. Herndon, D.N. Traber, D.L: Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury. Am J Physiol Lung Cell Mol Physiol 298(3), L427-36 (2010)
- [14] Soriano, F.G. Lorigados, C.B. Pacher, P. Szabó, C: Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis. Shock 35(6), 560-6 (2011)
- [15] Jangra, A. Datusalia, A.K. Sharma, S.S: Reversal of neurobehavioral and neurochemical alterations in STZ-induced diabetic rats by FeTMPyP, a peroxynitrite decomposition catalyst and 1,5-Isoquinolinediol a poly(ADP-ribose) polymerase inhibitor. Neurol Res 36(7), 619-26 (2014)
- [16] Shirai, H. Poetsch, A.R. Gunji, A. Maeda, D. Fujimori, H. Fujihara, H. Yoshida, T. Ogino, H. Masutani, M: PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways. Cell Death Dis 6, 4:e656 (2013)
- [17] Nakadate, Y. Kodera, Y. Kitamura, Y. Tachibana, T. Tamura, T. Koizumi, F: Silencing of poly(ADP-ribose) glycohydrolase sensitizes lung cancer cells to radiation through the abrogation of DNA damage checkpoint. Biochem Biophys Res Commun 29, 441 (4): 793-8 (2013)
- [18] Feng, X. Koh, D.W: Inhibition of poly(ADP-ribose) polymerase-1 or poly(ADP- ribose) glycohydrolase individually, but not in combination, leads to improved chemotherapeutic efficacy in HeLa cells. Int J Oncol 42(2), 749-56 (2013)
- [19] Murai, J. Shar-yin, N.H. Das, B.B. Renaud, A. Zhang, Y. Doroshow, J.H. Ji, J. Takeda, S. Pommier, Y: Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer Res 72, 5588–5599 (2012)
- [20] Kirsanov, K.I. Kotova, E. Makhov, P. Golovine, K. Lesovaya, E.A. Kolenko, V.M. Yakubovskaya, M.G. Tulin, A.V: Minor grove binding ligands disrupt PARP-1 activation pathways. Oncotarget 30;5(2):428-37 (2014)
- [21] Okuda, H. Nishida, K. Higashi, Y. Nagasawa, K: NAD(+) influx through connexin hemichannels prevents poly(ADP-ribose) polymerase-mediated astrocyte death. Life Sci 19, 92(13):808-14 (2013)
- [22] Bai, P. Cantó, C. Oudart, H. Brunyánszki, A. Cen, Y. Thomas, C. Yamamoto, H. Huber, A. Kiss, B. Houtkooper, R.H. Schoonjans, K. Schreiber, V. Sauve, A.A. Menissier-de Murcia, J. Auwerx, J: PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab 13(4), 461-8 (2011)
- [23] Chung, H.T. Joe, Y. Antagonistic crosstalk between SIRT1, PARP-1, and -2 in the regulation of chronic inflammation associated with aging and metabolic diseases. Integr med res in press (2014)
- [24] Mabley, J.G. Horváth, E.M. Murthy, K.G. Zsengellér, Z. Vaslin, A. Benko, R. Kollai., M. Szabó, C: Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation. J Pharmacol Exp Ther 315(2), 812-20 (2005)
- [25] Mahrouf-Yorgov, M. Marie, N. Borderie, D. Djelidi, R. Bonnefont-Rousselot, D. Legrand, A. Beaudeux, J.L. Peynet, J: Metformin suppresses high glucose-induced poly(adenosine diphosphate-ribose) polymerase overactivation in aortic endothelial cells. Metabolism 58(4), 525-33 (2009)