IMR Press / FBS / Volume 7 / Issue 1 / DOI: 10.2741/S432

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Drug repositioning in Alzheimer’s disease
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1 Wolfson Centre for Age-Related Diseases, King’s College London, London SE1 1UL

*Author to whom correspondence should be addressed.

Academic Editor: Christian Saleh

Front. Biosci. (Schol Ed) 2015, 7(1), 184–188;
Published: 1 June 2015
(This article belongs to the Special Issue The polyhedral aspects of dementia)

Drug repositioning offers an innovative approach to drug discovery with great potential in the field of Alzheimer’s Disease and dementia therapeutics. Investigation of licensed compounds enables processing through the drug discovery pipeline in a rapid and cost-effective manner. A growing body of evidence supports the translation of priority compounds to be taken forward to clinical trials, based on established and proposed mechanisms of action. A number of drugs have already entered clinical trial following repositioning, and novel technologies have been created to enable high-throughput screening. This review discusses the novel approaches that build on transcriptional signature profiling to support repositioning in AD, and the novel candidate drugs that are emerging from this exciting new technique.

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