IMR Press / FBS / Volume 7 / Issue 1 / DOI: 10.2741/S429

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Historical perspective of matrix metalloproteases
Show Less
1 Department of Pharmacology, Stony Brook University, Stony Brook, NY 11794

*Author to whom correspondence should be addressed.

Academic Editor: Jian Cao

Front. Biosci. (Schol Ed) 2015, 7(1), 125–149; https://doi.org/10.2741/S429
Published: 1 June 2015
(This article belongs to the Special Issue Matrix metalloproteinases in diseases)
Abstract

Matrix metalloproteinases (MMPs) were identified as early as 1962. Since this seminal finding, this family of zinc-dependent endopeptidases has been studied extensively. This collective work has resulted in delineation of MMP gene and protein structures, the mechanisms of control of MMPs, the action of MMPs on their substrates, and of course their role in normal physiology and their crucial roles in pathophysiology. Stemming from the discovery that MMPs contribute to arthritis, heart disease, and cancer, amongst other diseases, attempts to develop treatment strategies incorporating MMP inhibition have been undertaken. The results of these endeavours have been mediocre, resulting in few FDA-approved MMP inhibitors mostly due to the broad-spectrum nature of these early inhibitors and unwanted side effects of MMP inhibition. The future of exploitation of MMPs in disease lies in the design of more targeted inhibitors; in order to accomplish this, we must all understand the subtle differences between each MMP and their contextual roles. In this chapter, we aim to overview major topics regarding MMPs and what direction we may go in the future.

Keywords
Review
matrix metalloprotease
MMP structure
MMP regulation
MMP inhibitor
Review
Share
Back to top