IMR Press / FBS / Volume 6 / Issue 1 / DOI: 10.2741/S416

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Interactions of monocytes and platelets: implication for life
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1 Universitaet Muenster, Medizinische Klinik D, Experimentelle Nephrologie, Domagkstrasse 3a, 48149 Muenster, Germany
2 Nierenzentrum Nordhorn, Hohenkoerbener Weg 42a, 48527 Nordhorn, Germany
Front. Biosci. (Schol Ed) 2014, 6(1), 75–91; https://doi.org/10.2741/S416
Published: 1 January 2014
Abstract

Monocytes interact and cross-talk with platelets in many settings including inflammation, hemostasis, or vascular disorders. These interactions are important for the regulation of life span of both. During inflammatory diseases, there is a rapid recruitment of monocytes and platelets to the site of inflammation and endothelial injury where they act side-by-side. Adherence between monocytes/macrophages (Mphi) and platelets occur in the vessel wall and atherosclerotic plaque, but it is also shown in the blood stream where it has been called platelet satellitism. This phenomenon has been attributed to thrombotic disorders such as stroke. Furthermore, we discovered consequences for leukocyte apoptosis after the interaction with platelets. Herein, we reviewed the complex mechanism and interactions regulating the life span of both types of blood cells. We also provide a distinct focus on apoptosis of platelets and Mphi.

Keywords
Human Monocytes
Human Platelets
Phagocytosis
Apoptosis
Mphi
Review
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