IMR Press / FBS / Volume 6 / Issue 1 / DOI: 10.2741/S412

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Maintaining the reproductive potential of cancer patients during cancer treatment
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1 Department of Obstetrics and Gynecology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
2 Reproductive Science Research Program, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
3 Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Academic Editor:Indrajit Chowdhury
Front. Biosci. (Schol Ed) 2014, 6(1), 39–49; https://doi.org/10.2741/S412
Published: 1 January 2014
(This article belongs to the Special Issue Recent progress in reproductive biology)
Abstract

Cancer therapies are known to alter the reproductive potential in cancer patients. Due to improved survival rates in cancer patients of reproductive age, considerations of the long-term effects of cancer therapy have become more significant. Oncofertility is a new discipline in medicine that deals with maintaining the reproductive potential of cancer patients while they are receiving gonadotoxic cancer treatment. The purpose of this review is to explore how cancer treatment impairs reproductive functioning and present the current options for preservation of fertility in women. All patients with reproductive potential should be made aware of the possible treatment-related infertility and be offered appropriate fertility preservation options before cancer treatment is instituted. The hope is that, in the future, mechanism(s) can be developed to preserve immature germ cells in the ovary, so that they can be used for fertilization in vivo or in vitro.

Keywords
Oncofertility
Fertility Preservation
Chemotherapy
Radiotherapy
Gonadotoxic
Cryopreservation
Follicles
Review
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