IMR Press / FBS / Volume 5 / Issue 2 / DOI: 10.2741/S404

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Melatonin and clock genes expression in the cardiovascular system
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1 Department of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University Bratislava, Mlynska dolina B2, 842 15 Bratislava, Slovak Republic

*Author to whom correspondence should be addressed.

Academic Editors: Fedor Simko, Ludovit Paulis, Russel J Reiter

Front. Biosci. (Schol Ed) 2013, 5(2), 743–753;
Published: 1 January 2013
(This article belongs to the Special Issue Protective effects of melatonin in cardiovascular system)

Generation of circadian oscillations is based on rhythmic expression of clock genes and subsequent posttranscriptional and post-translational modifications. In addition to the central circadian oscillator - the suprachiasmatic nucleus (SCN), peripheral oscillators have been demonstrated in many tissues, including the heart and blood vessels. Melatonin mediates cyclic lighting conditions to rhythmic endocrine signal and is able to synchronize neuronal firing in the SCN via membrane receptors. Clock gene expression is melatonin sensitive in the pars tuberalis, genes cry1 and tim1 respond to single injection while neurod1 and npas4 are influenced via long lasting mechanisms. In the rat heart, melatonin phase advanced expression of per2 and bmal1 independently from its effects on the SCN. Melatonin is an important endogenous signal able to synchronize circadian oscillations in the cardiovascular system. It may be effective especially in situations when the circadian control is weakened or organism must adapt to rapid changes in rhythmic environmental conditions.

Circadian rhythms
Non- dipping
Blood pressure
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