Developmental regulation of decidual cell polyploidy at the site of implantation

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Julie M. Sroga^1,3, Xinghong Ma^1,2, Sanjoy K. Das^1,2,*

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¹ Division of Reproductive Sciences, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH

² Perinatal Institute, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH

³ Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH

*Author to whom correspondence should be addressed.

Academic Editor: Indrajit Chowdhury

Front. Biosci. (Schol Ed) 2012, 4(4), 1475–1486; https://doi.org/10.2741/S347

Published: 1 June 2012

(This article belongs to the Special Issue Recent progress in reproductive biology)

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Abstract

Polyploidy has been reported in several animal cells, as well as within humans; however the mechanism of developmental regulation of this process remains poorly understood. Polyploidy occurs in normal biologic processes as well as in pathologic states. Decidual polyploid cells are terminally differentiated cells with a critical role in continued uterine development during embryo implantation and growth. Here we review the mechanisms involved in polyploidy cell formation in normal developmental processes, with focus on known regulatory aspects in decidual cells.

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