IMR Press / FBS / Volume 3 / Issue 4 / DOI: 10.2741/232

Frontiers in Bioscience-Scholar (FBS) is published by IMR Press from Volume 13 Issue 1 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Neuroinflammation and cell therapy for Parkinson's disease
Show Less
1 Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, 250012, P. R. China
2 Department of Neurosurgery Neurology, Qilu Hospital of Shandong University, Jinan, 250012, P. R. China

*Author to whom correspondence should be addressed.

Academic Editor: Dongguang Wei

Front. Biosci. (Schol Ed) 2011, 3(4), 1407–1420;
Published: 1 June 2011
(This article belongs to the Special Issue Cell-based reconstructive therapy for neurological disorders)

Cell therapy is a promising therapeutic alternative for Parkinson's disease, and one possible limiting factor may be that the pathological environment of PD is hostile for the process of neurogenesis, including grafted stem cells survival, proliferation, migration and dopaminergic neuronal fate specification along with maturation of the immature neurons and ultimately integration of the new neuronal progeny into functional neuronal circuits. Uncontrolled microglial activation and neuroinflammation contributes to neuronal damage in PD. Similarly, the microglia-derived inflammatory mediators may also influence grafted stem cells. Thus, we discuss reactive microgliosis and sustained, chronic neuroinflammation in PD, together with cytokine-dependent neurotoxicity and inflammation-derived oxidative stress on dopaminergic neuron in the substantia nigra pars compacta substantia nigra pars compacta (SNpc). Based on these, we further summarize the interaction between neuroinflammation and stem cells, and conclude that neuroinflammation acts as double-edged swords, instead of simply beneficial or detrimental, and stem cells display immunomodulatory functions beneficial for dopaminergic neurons via an anti-inflammatory action in PD.

Back to top